COURSE UNIT TITLE

: ROLE IN CELL SIGNAL TRANSDUCTION AND DISEASE

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
TBG 6103 ROLE IN CELL SIGNAL TRANSDUCTION AND DISEASE ELECTIVE 3 0 0 10

Offered By

Medical Biology and Genetics

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR SAFIYE NEŞE ATABEY

Offered to

Medical Biology and Genetics

Course Objective

Understanding of the cellular and intracellular signaling mechanisms and the basis of cell-cell and cell-extracellular matrix interactions of eukaryotic cells. Formulating how signaling abnormalities lead to human diseases. Understanding the role of signaling pathways as future strategies for the prevention and treatment of human diseases.

Learning Outcomes of the Course Unit

1   Defines basic concepts of cell-cell, cell ECM interactions of eukaryotic cells.
2   Discusses basic signaling mechanisms that regulates cell-cell, cell ECM interactions
3   Knows main steps involved in cellular signaling
4   Describes main mechanisms involved in cellular communication and intracellular signaling,
5   Knows how does post translational modifications and protein-protein interactions effect cell-cell, cell-ECM interactions and intracellular signaling
6   Discusses the roles of signaling pathways in the development and progression of human diseases
7   Knows the roles of signaling molecules as biomarkers, or as targets for the prevention or treatment of human diseases.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Overview of cell- cell and cell ECM interactions
2 Basic concepts of cellular and intracellular signaling (CASE 1).
3 Basic concepts of cellular and intracellular signaling (Lecture).
4 Main mechanisms involved in cellular communication and intracellular signaling (CASE 2)
5 Main mechanisms involved in cellular communication and intracellular signaling (CASE 3)
6 Main mechanisms involved in cellular communication and intracellular signaling (Lecture)
7 The roles of post translational modifications and protein-protein interactions in signaling (CASE 4)
8 The roles of post translational modifications and protein-protein interactions in signaling (Lecture)
9 Student Presentations (concept maps)
10 ECM structure and functions
11 ECM in Human Health and Diseases (CASE 5)
12 The roles of MMPs in cellular signaling
13 ECM in Human Health and Diseases (CASE 5)
14 Literature review and concept maps
15 Literature review and concept maps
16 Final Exam

Recomended or Required Reading

A-Ön Bilgi
1. Molecular Biology of The Cell, Alberts et all;
2. The Cell: A Molecular Apporoach, Cooper
B-Ders Sırasında tartışılacak makaleler
1. Mythreye K, Blobe GC. Proteoglycan signaling co-receptors: Roles in cell adhesion, migration and invasion, Cellular Signalling 21 (2009) 1548 1558
2-Deribe YL, Pawson T , Dikic I Post-translational modifications in signal integration Nature Molecular& Structural Biology, 2010:666
3. Schmidt S, Friedl P.Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms Cell Tissue Res (2010) 339:83 92
4. Friedl P, Wolf K. Proteolytic interstitial cell migration: a five-step process Cancer Metastasis Rev (2009) 28:129
5. Fletcher DA, Mullins RD Cell mechanics and the cytoskeleton NATURE,Vol 463,28 January 2010

Planned Learning Activities and Teaching Methods

In this course , main learning method is Problem Based Learning . Learning objectives of the course will be given by case studies and related lectures . In addition:
Oral Presentations: Basic information, especially the subjects that are hard to understand or unreachable will be given by tutor.
Tutorials: Some up to date articles related to the basic subjects will be chosen and students will be asked to read and discuss.
Home Work: Several questions aiming to increase the synthesis and analysis abilities of students will be given and asked for a written report. In addition students prepares concept maps related to case studies.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 PRF PERFORMANCE
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE MTE * 0.20 +PRF * 0.30 + FIN* 0.50
5 RST RESIT
6 FCGR FINAL COURSE GRADE MTE * 0.20 +PRF * 0.30 +RST* 0.50

Further Notes About Assessment Methods

None

Assessment Criteria

Written Exams: At least 75% of questions should be answered correctly.
Concept maps: The group will be expected to prepare a concept map for each case and critique pointing out the concepts of the case study. Students will be expected to contribute to the discussion and critique of the case being presented in the class. (Reading the papers before the presentation is absolutely mandatory).

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

Tlf: 232. 4124600 or 232.4124601
nese.atabey@deu.edu.tr

Office Hours

From Monday to Friday at 12:00-13:00

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 2 30
Preparations before/after weekly lectures 15 3 45
Preparation for midterm exam 1 10 10
Preparation for final exam 1 10 10
Preparation for quiz etc. 2 5 10
Preparing Individual Assignments 5 9 45
preparation of the concept map 5 9 45
makale hazırlama 5 9 45
Final 1 3 3
Midterm 1 3 3
Quiz etc. 2 3 6
TOTAL WORKLOAD (hours) 252

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9
LO.11345
LO.21345
LO.312345
LO.41345
LO.512345
LO.61345
LO.71345

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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