COURSE UNIT TITLE

: GENE EXPRESSION REGULATION IN PROKARYOTES AND EUKARYOTES

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
TBG 6105 GENE EXPRESSION REGULATION IN PROKARYOTES AND EUKARYOTES ELECTIVE 2 0 0 6

Offered By

Medical Biology and Genetics

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSOCIATE PROFESSOR ZEYNEP YÜCE

Offered to

Medical Biology and Genetics

Course Objective

To acquire advance knowledge on transcriptional & translational control mechanisms in prokaryotes and eukaryotes.
*To conceptually understand the biology behind a fenotype

Learning Outcomes of the Course Unit

1   Knows and discusses the main concepts of genetic regulation
2   Explains prokaryotic transcriptional and translational regulation, compares to eukaryotic regultion
3   Explains the different mechanisms for transcriptional control in eukaryotes (while taking DNA structure and relevant biological processes into account)
4   Describes translational and post-translational mechanisms in eukaryotes. Discusses their role in expression control
5   Describes and compares epigenetic mechanisms
6   Explains and discusses RNA interference

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 An Introduction to Regulation of Gene Expression
2 Transcriptional control and regulation in Prokaryotes
3 Transcriptional control, cis-Element and trans-Factors in Eukaryotes
4 Transcriptional control and regulation in Eukaryotes
5 Expression control by translational regulation and protein degradation
6 Transient and stable expression blocks
7 RNA Interferance

Recomended or Required Reading

1. Hücre, Moleküler Yaklaşım, (The Cell, A Molecular Approach 2nd edition Geoffey M. Cooper, Robert E. Hausman.) Çeviri Editörleri: Meral Sakızlı, Neşe Atabey. Izmir Tıp Kitabevi, ISBN: 9944-5148-0-2, Ankara 2006 .
2. Hücrenin Moleküler Biyolojisi, (Molecular Biology of the Cell,4th Edition. Ed. Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter. Garland Publishers) Çeviri Editörleri: Nur Buyru, Nejat Dalay, Meral Özgüç, Mehmet Öztürk, Meral Sakızlı, ISBN: 978-9944-252-22-5, TÜBA ders kitapları, 2008

Planned Learning Activities and Teaching Methods

Lectures: Basic theoretical concepts will be explained during lectures
Homework: Students are expected to hand in 2 written reports on topics that are given by the course coordinator.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 PRF PERFORMANCE
2 FIN FINAL EXAM
3 FCG FINAL COURSE GRADE PO * 0.40 + FN*0.60
4 RST RESIT
5 FCGR FINAL COURSE GRADE (RESIT) PO * 0.40 + BUT*0.60

Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

412 4608 E-posta: zeynep.sercan@deu.edu.tr

Office Hours

Wednesday s 15:30-17:00

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 1 15
Preparations before/after weekly lectures 15 3 45
Preparation for Block Exam 1 10 10
Preparing Individual Assignments 9 8 72
Block Exam 1 3 3
TOTAL WORKLOAD (hours) 145

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9
LO.11234
LO.21234
LO.31234
LO.41234
LO.51234
LO.6234

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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