COURSE UNIT TITLE

: METASTASIS BIOLOGY

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
TBG 6114 METASTASIS BIOLOGY ELECTIVE 2 0 0 6

Offered By

Medical Biology and Genetics

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR SAFIYE NEŞE ATABEY

Offered to

Medical Biology and Genetics

Course Objective

Understanding of the common cellular and molecular mechanisms of tumor invasion and metastasis

Learning Outcomes of the Course Unit

1   Know basic concepts on tumor invasion and metastasis
2   Understand basic molecular mechanisms that leads tumor invasion and metastasis
3   List basic steps of tumor invasion and metastasis
4   Define the role of EMT in tumor metastasis
5   Describe the role of microenvironmental changes in tumor invasio and metastasis
6   Knows genetic determinants of tumor metastasis
7   Critique targeted molecular therapies in metastasis and underlying mechanisms

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Tumor Invasion and metastasis: Basic concepts, and metastasis theories
2 Case Discussion 1
3 Mechanisms of Tumor Invasion and Metastasis 1 (Prequisits for metastasis)
4 Literature discussion 1
5 Mechanisms of Tumor Invasion and Metastasis 1 (Rate limiting steps for metastasis)
6 Literature discussion 2
7 The role of EMT in tumor invasion and metastasis
8 Case Discussion 2
9 Genetic Determinants of Tumor Metastasis
10 Literature Discussion 3
11 The role of tumor microenvironment in tumor invasion and metastasis (hypoxia, pH and glycose levels)
12 Case Discussion 3
13 The role of tumor microenvironment in tumor invasion and metastasis (CAFs, Myofibroblasts and macrophages)
14 The role of tumor microenvironment in tumor invasion and metastasis (ECM (laminin, collagen and MMPs) and ECM remodeling)
15 Presentation of concept maps

Recomended or Required Reading

1. Tumor metastasis: molecular insights and evolving paradigms.
Valastyan S, Weinberg RA.Cell. 2011 Oct 14;147(2):275-92. Review.
2. Hypoxic stress and cancer: imaging the axis of evil in tumor metastasis.Avni R, Cohen B, Neeman M.NMR Biomed. 2011 Jul;24(6):569-81. doi: 10.1002/nbm.1632. Epub 2011 Jan 17.
3. The heparanase system and tumor metastasis: is heparanase the seed and soil Arvatz G, Shafat I, Levy-Adam F, Ilan N, Vlodavsky I.Cancer Metastasis Rev. 2011 Jun;30(2):253-68.
4. Selectins promote tumor metastasis.Läubli H, Borsig L.
Semin Cancer Biol. 2010 Jun;20(3):169-77. Epub 2010 May 7. Review.
5. The microRNA network and tumor metastasis.Zhang H, Li Y, Lai M.
Oncogene. 2010 Feb 18;29(7):937-48. Epub 2009 Nov 23. Review.
6. Inflammation: a driving force speeds cancer metastasis.
Wu Y, Zhou BP.Cell Cycle. 2009 Oct 15;8(20):3267-73. Epub 2009 Oct 3. Review

Planned Learning Activities and Teaching Methods

Case Discussions: The mechanisms will be discussed by using PBL cases
Oral Presentation: Basic information, especially the subjects that are hard to understand or unreachable will be given by tutor.
Article Discussion: Some up to date articles related to the basic subjects will be chosen and students will be asked to read and discuss.
Home Work: Several questions aiming to increase the synthesis and analysis abilities of students will be given and asked for a written report.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 PRF PERFORMANCE
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE MTE * 0.20 +PRF * 0.30 + FIN* 0.50
5 RST RESIT
6 FCGR FINAL COURSE GRADE MTE * 0.20 +PRF * 0.30 +RST* 0.50

Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

tlf.24601, 24600. nese.atabey@deu.edu.tr

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 1 15
Preparations before/after weekly lectures 15 3 45
Preparation for midterm exam 1 10 10
Preparation for final exam 1 10 10
Preparation for quiz etc. 1 10 10
Preparing Individual Assignments 1 10 10
preparation of the concept map 5 4 20
manuscript preparation 5 4 20
Final 1 3 3
Midterm 1 3 3
Quiz etc. 1 3 3
TOTAL WORKLOAD (hours) 149

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9
LO.112345
LO.212345
LO.312345
LO.412345
LO.512345
LO.612345
LO.712345

CONTACT INFORMATION
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Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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