COURSE UNIT TITLE

: ANTIMICROBIALS AND RESISTANCE MECHANISMS

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
MIK 6041 ANTIMICROBIALS AND RESISTANCE MECHANISMS ELECTIVE 2 0 0 6

Offered By

Microbiology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR ZEYNEP GÜLAY

Offered to

Microbiology

Course Objective

Understand antibiotics, antifungals, antiviral mechanisms and also the relation between pharmacokinetics / pharmacodynamic properties and efficiency of drugs. Can cope molecular mechanisms of resistance against antibiotics used in treatment and be able to describe resistance mechanism and their effects of clinical resistance patterns as well as antifungal, antimycobacterial and antiviral resistance mechanisms.Understand antibiotics, antifungals, antiviral mechanisms and also the relation between pharmacokinetics / pharmacodynamic properties and efficiency of drugs. Can cope molecular mechanisms of resistance against antibiotics used in treatment and be able to describe resistance mechanism and their effects of clinical resistance patterns as well as antifungal, antimycobacterial and antiviral resistance mechanisms.

Learning Outcomes of the Course Unit

1   Be able to identify mechanisms of action of antibiotics and understand the importance of pharmacodynamic and pharmacokinetic properties of the antibiotics.
2   Be able to define the gene groups and specielized gene groups and elemnets which involved antibacterial resistancy.
3   Understand and apply methods which is used to detect responsible genes of resistancy
4   Mechanisms of action of antifungal agents and to associate with the resistance change related targets
5   Know that describe the basic principles of antiviral therapy and to associate with resistance mechanisms

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 General properties of antimicrobial agents
2 Measurements of antimicrobial resistance principles of pharmacodynemia and pharmacokinetics
3 Beta-lactam antibiotics and molecular mechanisms of resistance to beta-lactam antibiotics
4 Molecular mechanisms of resistance to glycopeptides
5 Inhibitors of protein synthesis
6 Quinolone antibiotics and molecular basis of resistance
7 Folate synthesis inhibitors and molecular mechanisms of resistance
8 Detection of resistance by molecular methods used in the follow-up of resistant bacteria
9 Important mechanisms of resistance in Helicobacter and Campylobacter species and their detection
10 Fungal resistance assays
11 Antituberculosis agents and mechanisms of resistance
12 Viral resistance assays

Recomended or Required Reading

Frontiers in Anrimicrobial resistance . White DG, Alekshun MN, McDermott PF (ed), 2005 ASM Press Washington DC
Manual of Clinical Microbiology 10th ed, CLSI Antibiyotik Duyarlıklık Test Yöntemleri M100-S22
Antimicrobial Susceptibility Testing (CD Rom), CDC

Planned Learning Activities and Teaching Methods

Assessment Methods

Successful / Unsuccessful

Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

zeynepgulay62@gmail.com, zeynep.gulay@deu.edu.tr, Tel 24501-24503

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 30 2 60
Student Presentations 1 2 2
Preparations before/after weekly lectures 30 1 30
Preparation for final exam 1 20 20
Preparing assignments 1 8 8
Preparing presentations 1 8 8
Web Search and Library Research 30 1 30
Final 1 2 2
TOTAL WORKLOAD (hours) 160

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12
LO.15253
LO.252534
LO.3555
LO.45535
LO.5554

CONTACT INFORMATION
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Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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