COURSE UNIT TITLE

: THE SIGNAL TRANSDUCTION MECHANISMS OF CANCER CELLS

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
ONK 6072 THE SIGNAL TRANSDUCTION MECHANISMS OF CANCER CELLS ELECTIVE 1 0 0 3

Offered By

Basic Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSOCIATE PROFESSOR ZEKIYE SULTAN ALTUN

Offered to

Basic Oncology

Course Objective

Define and understanding of the molecular biology of cancer, signal transduction, receptors and ligands engaged by the issue of concepts and their reflection of the clinic. Define and understanding of the changes in cell division and signaling mechanisms in cancer, cancer, and molecular targets of signal transduction systems, control of the transcriptional regulators, and the signal of a transduction mechanism of clinically relevant cancers, particularly lung cancer.

Learning Outcomes of the Course Unit

1   Capable of express in general terms of signal transmission mechanisms in the context of the molecular biology of cancer.
2   Be able to recognize and understand the cancer signal transduction systems and molecular targets, molecular mechanisms of control of transcriptional regulators.
3   Knows signal mechanisms of clinically relevant cancers with examples of specific types of cancer
4   Understands changes in signaling in cell division and the life of cancer cells.
5   Be able to criticize and plan the signal transduction mechanisms of cancer cells

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 The overview of signaling of cancer cells
2 Differences from normal cell to cancer cell signaling
3 Ligands and receptors in cancer cell signaling
4 Transduction of signaling to the cancer cell (protein kinases, protein phosphatase, lipid kinases, lipid phosphatase, phospholipases, nucleotide cyclases, GTPs, ..)
5 Multiprotein signaling complexes formation (domains and motifs)
6 Control in transduction of signaling and protein level (Regulation of Protein Levels: Transcription, Translation, and Proteolysis)
7 Changes in cell cycle and life of cancer cells- I
8 Changes in cell cycle and life of cancer cells- II
9 Changes in cell cycle and life of cancer cells- III
10 Systems of cancer signaling and molecular targets
11 Control of cancer signal transduction and transcriptional regulators
12 Signal transduction and transcription factors in Lung Cancer
13 Signal transduction and transcription factors in Breast Cancer
14 Signal transduction and transcription factors in Colon Cancer
15 Signal transduction and transcription factors in Prostate Cancer
16 Final Exam

Recomended or Required Reading

1. Textbook(s): Diagnostic Approach to Clinical Oncology Mario W. Fiorentino PICCIN 1999
2. Molecular Biology in Cancer Medicine. Razelle Kurzrock, Moshe Talpaz, Martin Dunitz 1995.
3. AJCC Cancer Staging Handbook.Irvin D. Fleming. Lippincott Willams & Wilkins 1998
4. Manual of Clinical Oncology. D.K. Hossfeld, C.D. Sherman, R.R. Love, F.X. Bosch Springer- Verlag, 1990 Fith Edition.
5. Pathologic Basis of Disease. Vinay Kumar, Abul K. Abbas, Nelson Fausto, Elsevier Saunderss, 2005 Seventh Edition
6. Molecular Mechanism of Cancer. Georg F. Weber, Springer 2007
7. The Biology of Cancer Robert A. Weinberg, Gariand Science 2007
8. Molecular biology of the gene Watson JD, et al. 2004 Fifth edition .
9. Cancer Principles and Practice of Oncology Devita VT, Lawrence TS, Rosenberg SA, Wolters Kluwer& Lippincott Willams & Wilkins 2008 Eighth Edition

Planned Learning Activities and Teaching Methods

Theoretical and practical courses done, discussed the importance of signaling pathways in the particular type of cancer, properties of and importance of signaling pathways in at given assignment and final exam done.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 PRF PERFORMANCE
2 FIN FINAL EXAM
3 FCG FINAL COURSE GRADE PO * 0.40 + FN*0.60
4 RST RESIT
5 FCGR FINAL COURSE GRADE (RESIT) PO * 0.40 + BUT*0.60

Further Notes About Assessment Methods

None

Assessment Criteria

1.Being able to express in general terms the signal transduction mechanisms in molecular biology of cancer , prepared homework related to a features and importance of particular type of cancer signaling pathway will be assessed.
2. To question the making of intermediate and searching capabilities related to molecular biology of cancer signaling researches will be evaluate with final exam.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

Zekiye Altun
zekiye.altun@deu.edu.tr 0 232 4125871/5801

Office Hours

on Tuesday at: 13.30-16.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 1 15
Preparation for final exam 1 36 36
Preparing assignments 1 21 21
Final 1 3 3
TOTAL WORKLOAD (hours) 75

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11
LO.1555555
LO.25555555555
LO.3555555555
LO.455555555
LO.555555555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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