COURSE UNIT TITLE

: CELL DEATH AND BIOLOGY OF CANCER

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
ONK 6073 CELL DEATH AND BIOLOGY OF CANCER ELECTIVE 1 0 0 3

Offered By

Basic Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSOCIATE PROFESSOR ZEKIYE SULTAN ALTUN

Offered to

Basic Oncology

Course Objective

Understand the biological mechanisms of cell death in oncology, molecular and genetic characteristics and molecular mechanisms of cell death.

Learning Outcomes of the Course Unit

1   Capable of express in general terms the cell death.
2   Be able to recognize and understand the molecular mechanisms and role of cancer cell death in the development of cancer.
3   Be able to understand the molecular basis of cancer cell death mechanism in anticancer therapy.
4   Knows the general methods used to determine in cell death.
5   Be able to criticize and plan the studies related to cell death in oncology.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Overview of cell death
2 Necrotic cell death
3 Programmed cell death /mechanisms of apoptosis
4 Regulation of apoptosis
5 Signaling pathways leading to cell death
6 Analyzing methods of apoptosis
7 Cancer therapies and Apoptosis
8 Mechanisms of autophagy
9 Autophagy and signaling pathways
10 Regulation of autophagy
11 Analyzing methods of autophagy
12 Cancer therapies and autophagy
13 DNA damage and cancer
14 Inhibitory RNA's and cell death
15 Cancer and cell death models
16 Final Exam

Recomended or Required Reading

Textbook(s):
1. Use and Interpretation of Laboratory Tests in Oncology. Douglas C. Aziz, Specialty Laboratories. Third edition 1998
2. Chemosensitivity Testing in Oncology. U. Rainhold W. Tilgen Springer 2003
3. Diagnostic Approach to Clinical Oncology Mario W. Fiorentino PICCIN 1999
4. Molecular Biology in Cancer Medicine. Razelle Kurzrock, Moshe Talpaz, Martin Dunitz 1995.
5. Tumor Models in Cancer Research Beverly A. Teicher Humana Pres 2002
6. AJCC Cancer Staging Handbook.Irvin D. Fleming. Lippincott Willams & Wilkins 1998
7. Manual of Clinical Oncology. D.K. Hossfeld, C.D. Sherman, R.R. Love, F.X. Bosch Springer- Verlag, 1990 Fith Edition.
8. Pathologic Basis of Disease. Vinay Kumar, Abul K. Abbas, Nelson Fausto, Elsevier Saunderss, 2005 Seventh Edition
9. Molecular Mechanism of Cancer. Georg F. Weber, Springer 2007
10. The Biology of Cancer Robert A. Weinberg, Gariand Science 2007

Planned Learning Activities and Teaching Methods

Theoretical courses done, the importance of using the mechanisms of cell death associated with a particular type of cancer are discussed, and the importance of mechanisms related to feature for this type of cancer and a written given homework done in scientific format, and final exam done.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 PRF PERFORMANCE
2 FIN FINAL EXAM
3 FCG FINAL COURSE GRADE PO * 0.40 + FN*0.60
4 RST RESIT
5 FCGR FINAL COURSE GRADE (RESIT) PO * 0.40 + BUT*0.60

Further Notes About Assessment Methods

None

Assessment Criteria

1. Being able to express in general terms of cell death and cancer biology, to be prepared by using the mechanisms of cell death associated with the discussion of the importance of a particular type of cancer, the mechanisms for this type of cancer and about the importance of property to be evaluated with the preparation of homework.
2. The general methods used in cell death and cancer biology to know will be evaluated with final exam.
3. To question the making of intermediate and searching capabilities related to cell death and cancer biology researches will be evaluate with homework and final exam.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

zekiye.altun@deu.edu.tr 0 232 4125871/5801

Office Hours

on Tuesday at: 13.30-16.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 1 15
Preparation for final exam 1 36 36
Preparing assignments 1 21 21
Final 1 3 3
TOTAL WORKLOAD (hours) 75

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11
LO.15555555
LO.25555555555
LO.355555555
LO.455555
LO.555555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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