COURSE UNIT TITLE

: PRINCIPLES OF TUMOR IMMUNOLOGY

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
ONK 6078 PRINCIPLES OF TUMOR IMMUNOLOGY ELECTIVE 2 2 0 9

Offered By

Basic Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR SAFIYE AKTAŞ

Offered to

Basic Oncology

Course Objective

The aim of this course is to understand tumor immunology, and to learn its role in cancer therapy. Future aspects of tumor immunology is planned to be tought.

Learning Outcomes of the Course Unit

1   Capable of understanding tumor antigens, mechanisms of immune responses to tumor, relationship of immune insuffuciency syndromes and cancer.
2   Be able to understand properties of cytokines, B and T lymphocytes, NK cells, regulatory T cells, dendritic cells and their roles in tumor.
3   Be able to identfy immunologic escape mechanisms of tumor cell.
4   Be able to understand immunotherapy principles.
5   Capable of doing laboratory work about immunology.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Principles of Immun System
2 Tumor Antigens
3 Immunsupression and Cancer
4 Immun Response to Tumor and Spontaneous Regression
5 Relationship of HLA System with Cancer
6 Antigen Presentation in Cancer
7 Humoral Immunity and Cancer
8 Cellular Immunity and Cancer
9 Immunologic Methods in Cancer Diagnosis
10 Escape of cancer cell from Immune System
11 Monoclonal antibodies in cancer therapy
12 12. Adoptive cell therapy in cancer 13. Cytokines in cancer therapy 14. Vaccines in cancer 15. Future Aspects in Cancer Immunotherapy

Recomended or Required Reading

1. Molecular Biology in Cancer Medicine. Razelle Kurzrock, Moshe Talpaz, Martin Dunitz 1995.
2. Immunology. Ivan Roitt, Jonathan Brostoff , David Male. Mosby,1998 Fourth Edition
3. Basic & Clinical Immunology. Daniel P. Stites, John D. Stobo, J. Vivian Wells . Appleton& Lange, 1987 Six Edition
4. Dendritic Cell Protocols Stephen P. Robinson, Andrew J. Stagg, Humana Press 2002
5. Molecular Mechanism of Cancer. Georg F. Weber, Springer 2007
6. The Biology of Cancer Robert A. Weinberg, Gariand Science 2007
7. Cellular and Molecular Immunology eds. Abul Abbas, Lichtman Ah, Pober JS. Saunders Company 1991 Philadelphia, USA.
8. Immunology . 4th ed. Ed. Roitt, Brostoft. Mosby, London, 1998.

Planned Learning Activities and Teaching Methods

Theoretical Lectures, Giving a homework, Working for exams, Reading practices

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 PRF PERFORMANCE
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE MTE * 0.20 +PRF * 0.20 + FIN* 0.60
5 RST RESIT
6 FCGR FINAL COURSE GRADE MTE * 0.20 +PRF * 0.20 +RST* 0.60

Further Notes About Assessment Methods

None

Assessment Criteria

Learning outcomes will be assessed with classical questions of mid-term and final exams. The homework on the topic of reading and evaluating 5 different types of papers about tumor immunology will help in evaluating the learner understood the topics.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

safiye.aktas@deu.edu.tr 0 232 4125891/5801

Office Hours

on Monday at: 13.30-16.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 30 1 30
Tutorials 30 1 30
Preparation for Mid-term Exam 1 50 50
Preparation for Final Exam 1 50 50
Preparing Individual Assignments 1 50 50
Final 1 4 4
Mid-term 1 4 4
TOTAL WORKLOAD (hours) 218

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11
LO.15
LO.25
LO.35
LO.45
LO.55555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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