COURSE UNIT TITLE

: CANCER BIOLOGY AND GENETICS

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
ONK 6083 CANCER BIOLOGY AND GENETICS ELECTIVE 2 0 0 6

Offered By

Basic Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSOCIATE PROFESSOR YASEMIN BASKIN

Offered to

Basic Oncology

Course Objective

The aim of this course, the emergence of cancer as a clinical process is the regaining of the basic information about the biological and genetic processes.

Learning Outcomes of the Course Unit

1   The basic mechanisms of cancer cell biology can be expressed with the main lines
2   Be able to know the basic processes in the genetics of cancer
3   Be able to know the differences of cancer cell biology and genetic processes than normal cells
4   Be able to discuss the function of oncogenes and tumor suppressor genes in carcinogenesis
5   Be able to Interpret the multistep process of cancer
6   Be able to critically evaluates the multistep carcinogenesis

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction to cell biology (cancer burden, oncogenesis and cell cycle)
2 Molecular structures that control the cell cycle (genes and proteins)
3 Fundamental processes of cell genetics (replication, transcription, translation, DNA repair)
4 Physical carcinogenesis, chemical carcinogenesis, the molecular basis of viral carcinogenesis, mechanisms of carcinogenesis
5 Structure and function of oncogenes (ras, myc)
6 Effective mechanisms for the regulation of tumor suppressor genes and their functions RB1, WT1, MEN1, FAP1, p53, APC
7 Chromosomal stability, chromosomal translocations, Telomeres and cancer
8 Apoptosis and its regulation
9 Transcription factors in oncogenesis, growth factor receptors and signal transduction,
10 The nuclear receptor superfamily
11 GTP-binding proteins, protein-protein interactions Cytoplasmic protein kinases and phosphatases, secondary messengers
12 Adhesion molecules and cell matrix
13 Invasion and metastasis,
14 Angiogenesis in tumors and molecular mediators of angiogenesis
15 Relationships and mechanisms of antineoplastic drugs

Recomended or Required Reading

Textbook(s): Molecular Mechanism of Cancer. Georg F. Weber, Springer,2007.
Pathologic Basis of Disease. Vinay Kumar, Abul K. Abbas, Nelson Fausto, Elsevier Saunderss, 2005 Seventh Edition;
The Biology of Cancer Robert A. Weinberg, Gariand Science 2007;
Moleküler Biyoloji, Editör: Ahmet Yıldırım Nobel Yayın Dağıtım; Ankara, 2010,
Referanslar:
Materials: Pubmed

Planned Learning Activities and Teaching Methods

Theoretical Lectures, the topics in-class activities (presentations and assignments) to consolidate and discussion

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 PRF PERFORMANCE
2 FIN FINAL EXAM
3 FCG FINAL COURSE GRADE PO * 0.40 + FN*0.60
4 RST RESIT
5 FCGR FINAL COURSE GRADE (RESIT) PO * 0.40 + BUT*0.60

Further Notes About Assessment Methods

None

Assessment Criteria

1. The learner will clearly define outlined LO1,LO2, LO3 which will evaluate with exam.
2. The learner will recognize LO4, LO5, LO6, will evaluate with homework, prepared presentations by themselves and exam.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

yasemin.baskin@deu.edu.tr 0 232 4125890/5801

Office Hours

Monday 12.30-13.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 1 15
Preparation for midterm exam 1 48 48
Preparation for final exam 1 60 60
Preparing assignments 1 25 25
Final 1 1 1
Midterm 1 1 1
TOTAL WORKLOAD (hours) 150

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11
LO.15555
LO.25555
LO.35555
LO.4555
LO.5555555
LO.6555555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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