COURSE UNIT TITLE

: MECHANISMS OF CARCINOGENESIS

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
ONK 6101 MECHANISMS OF CARCINOGENESIS ELECTIVE 1 0 0 3

Offered By

Basic Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSOCIATE PROFESSOR ZEKIYE SULTAN ALTUN

Offered to

Basic Oncology

Course Objective

The aim of this course is to understand the mechanisms of carcinogenesis and related Factors which contribute to carcinogenesis by viral, chemical and physical carcinogenic agents and stages of cancer formation.

Learning Outcomes of the Course Unit

1   Capable of understanding effective viral, physical and chemical carcinogenic agents, and molecular biological characterization of their composition and properties of biological changes in carcinogenesis.
2   Be able to explain cancer deveoplment by different kinds of carcinogenic agents
3   Be able to know the role of viral carsinogenic agents in carsinogenesis
4   Be able to know the role of chemical carsinogenic agents in carsinogenesis.
5   Be able to know the role of physical carsinogenic agents in carsinogenesis
6   Be able to understand the Issues related genes in the development stages of carcinogenesis and molecular carcinogenesis characteristics and clinical image.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 The concept of carcinogenesis
2 Theories of carsinogenesis
3 Chemical carcinogenesis
4 Chemical carcinogenesis and mechanisms
5 Viral carcinogenesis (DNA virusus and carsinogenesis mechanisms)
6 Viral carcinogenesis (RNA virusus and carsinogenesis mechanisms)
7 Physical carsinogenic agents and mechanisms
8 Physical carsinogenic agents and mechanisms
9 Presentations of homeworks
10 Smoke and carsinogenesis
11 Genetic suspectibility to carsinogenesis
12 Determination of carsinogenic agents
13 carsinogenic agents and DNA repair
14 Evaluation of carsinogenesis in example of lung cancer
15 Presentations of reviews and evaluation

Recomended or Required Reading

1. Diagnostic Approach to Clinical Oncology Mario W. Fiorentino PICCIN 1999
2. Molecular Biology in Cancer Medicine. Razelle Kurzrock, Moshe Talpaz, Martin Dunitz 1995.
3. AJCC Cancer Staging Handbook.Irvin D. Fleming. Lippincott Willams & Wilkins 1998
4. Manual of Clinical Oncology. D.K. Hossfeld, C.D. Sherman, R.R. Love, F.X. Bosch Springer- Verlag, 1990 Fith Edition.
5. Pathologic Basis of Disease. Vinay Kumar, Abul K. Abbas, Nelson Fausto, Elsevier Saunderss, 2005 Seventh Edition
6. Molecular Mechanism of Cancer. Georg F. Weber, Springer 2007
7. The Biology of Cancer Robert A. Weinberg, Gariand Science 2007

Planned Learning Activities and Teaching Methods

Theoretical Lectures, Giving a homework, Working for exams, Reading practices

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 ASG ASSIGNMENT
2 SEM SEMINAR
3 FCG FINAL COURSE GRADE ASG * 0.40 + SEM * 0.60

Further Notes About Assessment Methods

None

Assessment Criteria

Learning outcomes will be assessed with writing review related to carsinogenesis mechanisms in different types of cancers. The homework on the topic of special cancer types and their molecular mechanisms related to viral, physical and chemical agents.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

zekiye.altun@deu.edu.tr 0 232 4128204/8201

Office Hours

on Tuesday at: 13.30-16.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 1 15
Preparations before/after weekly lectures 15 1 15
Preparing assignments 1 15 15
Preparing presentations 1 30 30
TOTAL WORKLOAD (hours) 75

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11
LO.155
LO.255
LO.355
LO.455
LO.555
LO.6

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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