COURSE UNIT TITLE

: MOLECULAR MEDICINE: MOLECULAR MECHANISMS IN DIAGNOSIS AND TREATMENT APPROACHES OF DISEASES

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
MOT 6034 MOLECULAR MEDICINE: MOLECULAR MECHANISMS IN DIAGNOSIS AND TREATMENT APPROACHES OF DISEASES ELECTIVE 2 2 0 9

Offered By

Molecular Medicine

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASISTANT PROFESSOR MEHTAP YÜKSEL EĞRILMEZ

Offered to

Molecular Medicine

Course Objective

Recent studies highlightened the molecular mechanisms of the diseases in detail. This resulted in developing new approaches to the diagnosis and treatment of the diseases. The aim of this course is to study the diseases systemically and to discuss the molecular mechanisms of diseases such as cancer, diabetes, atherosclerosis, asthma, Alzheimer s Disease and to analyse the molecular targets for the diagnosis and to evaluate new therapy trends. Nanoparticular systems, which are used as multifunctional platforms for molecular imagining and treatment, will also be discussed in detail.
In the practicals related to the course, cases will be used to discuss the molecular mechanisms of the diseases and to analyse already known or candidate molecules (ie, enzymes, transcription factor, miRNAs). Finally, therapeutical approaches will be discussed related to the molecular mechanisms of the diseases.

Learning Outcomes of the Course Unit

1   Define and recall the mechanisms of the diseases and molecular approaches for the diagnosis and treatment of the diseases
2   Describe the theoretical basis of the mechanisms of the diseases and molecular approaches for the diagnosis and treatment of the diseases
3   Analyse the relationship between mechanisms of the diseases and molecular approaches for the diagnosis and treatment of the diseases
4   Discuss the mechanisms of the diseases and molecular approaches for the diagnosis and treatment of the diseases (Ex: Gene therapy, stem cell therapy, nanomedicine)
5   Evaluate the materials design which makes diagnosis and treatment more effective and compare the advantages of these materials with traditional systems
6   Design new molecular approaches for the diagnosis and treatment of the diseases by using the mechanisms of the diseases

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction, Overview of Molecular Mechanisms of Diseases, Molecular Approaches to Diagnosis and Treatment of Diseases;Genetic Diseases;Metabolic Disorders;Infectious Diseases;Cardiovascular Diseases Molecular Mechanisms of Diseases Molecular Approaches to Diagnosis and Treatment of Diseases Small Group Work Practice
2 Carsinogenesis, Cell Cycle Regulatory Molecules, Molecular Mechanisms of DNA Repair, Oncogenes, Tumour Supressor Genes, Cell Adhesion Regulatory Molecules, Cell Adhesion Regulatory Molecules, Biology of Tumour Growth; Molecular Mechanisms of Angiogenesis, Invasion and Angiogenesis;Molecular Mechanisms of Solid Tumours;Neurologic Diseases;Psychiatric Disorders Molecular mechanisms of Head and Neck, Lung, GIS, Breast-Endocrine, CNS tumours; Comparison of Molecular Mechanisms of Adult Tumours with Childhood Tumours Molecular Mechanisms of Neurologic and Psychiatric Diseases Molecular Approaches to Diagnosis and Treatment of Neurologic and Psychiatric Diseases Small Group Work Practice
3 Presentations;Autoimmune Diseases;Endocrine Diseases;Gastrointestinal Diseases;Hematologic Diseases Molecular Mechanisms of Diseases Molecular Approaches to Diagnosis and Treatment of Diseases Small Group Work Practice
4 Pharmacogenetic Approaches in Treatment of Diseases;Biopharmaceuticals;Stem Cell Therapy;Gene Therapy;Nanomedicine in Diagnosis and Treatment of Diseases;Final exam Small Group Work Practice

Recomended or Required Reading

1-Textbook of Clinical Chemistry and Molecular Diagnostics. Eds: Burtis CA, Ashwood ER, Bruns DE, 4th edition, 2006, Elsevier Saunders, St Louis.
2-Biology of Disease. Eds: Ahmed N, Dawson M, Smith, Wood E, 2007, Taylor & Francis Group, New York.
3-Harper s Illustrated Biochemistry Murray, Bender, Rotham, Kennelly Rodwell and Weil, 28th Edition, 2009,McGraw Hill International Edition.
4-Textbook of Biochemistry with Clinical Correlations. Thomas M. Devlin. Seventh Edition 2011, John-Wiley& Sons Inc. Publication, USA.
5-Newsholme, EA and Leech, TR. Functional Biochemistry in Health and Disease 2010, WILEY-BLACKWELL, Oxford.
6-Tietz: Klinik Kimyada Temel Ilkeler Beşinci Baskı. (Editörler: Burtis & Ashwood) (Çeviri Editörü: Diler Aslan).PALMY yayıncılık.
7-Goodman & Gilman's The Pharmacological Basis of Therapeutics , 2012 .
8-Rang and Dale s Pharmacology, 7th. Edition, 2011
9-Klinik Farmakolojinin Esasaları ve Temel Düzenlemeler, Oğuz Kayaalp, 4. Baskı, 2008.

Planned Learning Activities and Teaching Methods

The course will be run in an integrated way-winding theory with case discussion and laboratory practicals. The methods of learning will be interactive.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 ASG ASSIGNMENT
2 PAR PARTICIPATION
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE ASG * 0.30 +PAR * 0.30 +FIN* 0.40
5 RST RESIT
6 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.30 +PAR * 0.30 +RST* 0.40

Further Notes About Assessment Methods

None

Assessment Criteria

Describe, learn, analyse, compare, apply, interactive discussion

Language of Instruction

Turkish

Course Policies and Rules

The student is expected to read the resources before coming to class. In addition, he/she is expected to contribute actively to discussion, group-work and case study practices. Plagiarism of any type will result in disciplinary action.

Contact Details for the Lecturer(s)

Mehtap Yüksel Eğrilmez
e-mail: mehtap.yuksel@deu.edu.tr Phone: 412 2606

Office Hours

Fridays 12.30-13.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 30 2 60
Tutorials 30 2 60
Preparations before/after weekly lectures 30 2 60
Preparation for final exam 1 25 25
Preparing presentations 1 18 18
Final 1 2 2
TOTAL WORKLOAD (hours) 225

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12PO.13PO.14
LO.155335534434224
LO.255335534444224
LO.355335534444224
LO.455445534444334
LO.555445534444334
LO.655445534444334

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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