COURSE UNIT TITLE

: TRANSLATIONAL RESEARCH METHODS II

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
TRO 6008 TRANSLATIONAL RESEARCH METHODS II ELECTIVE 1 2 0 15

Offered By

Translational Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR YASEMIN BAŞBINAR

Offered to

Translational Oncology

Course Objective

Translational perspective (from the bed to the lab from the lab to the bed) in cancer, research methods in Preventive Oncology (individuals cancer risk, screening programs and testing; environmental carcinogenesis, Nutrigenomics, population genetics concepts), research methods in Basic Oncology (the diagnostic laboratory techniques; tumor markers), research methods in Clinical Oncology (treatment response, tumor models (in vivo (experimental animals) in vitro (tissue culture), ex vivo models)
advanced molecular methods (hybridization, FISH, flow cytometry, genomics, proteomics, metabolamik, systems biology,molecular cloning, DNA sequencing) in cancer research, treatment technologies (recombinant protein technology,nanobiotechnology, drug design, pharmacogenomics studies, cancer vaccines, cellular modulations) will be discussed.

Learning Outcomes of the Course Unit

1   1. Capable of implementing advance molecular epidemiological techniques for cancer research.
2   2. Be able to recognize and comprehend the clinical trial in cancer
3   3. Be able to critically evaluates the published literature in the field of cancer research methods
4   4. Be able to recognize and comprehend the treatment technologies
5   5. Be able to recognize and comprehend the molecular diagnostics in cancer
6   6. Be able to establish a laboratory on cancer research.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 The research methods used in Preventive Oncology (identification of individuals at risk for cancer, screening programs and testing; environmental carcinogenesis, Nutrigenomics, population genetics),
2 The clinical oncology research methods (laboratory techniques for diagnosis, tumor markers),
3 The research methods used in clinical oncology (treatment response techniques, tumor models (in vivo (animal experiments) in vitro (tissue culture), ex vivo models)
4 Biobanking in cancer research
5 Basic research methods used in oncology (basic laboratory principles)
6 Basic research methods used in oncology (basic techniques)
7 Cell culture and associated methods in cancer research,
8 Advanced molecular methods in cancer research (hybridization, FISH, flow cytometry, etc.)
9 Advanced molecular methods in cancer research (genomics, proteomics, metabolamik, systems biology)
10 Advanced molecular methods in cancer research (molecular cloning, DNA sequencing)
11 Treatment technologies in cancer research (treatment techniques, recombinant protein technology)
12 Treatment technologies in cancer research (nanobiotechnology, drug design,)
13 Treatment technologies in cancer research (pharmacogenomics studies, cancer vaccines, cellular modulations)
14 Translational Research Planning
15 Translational Research

Recomended or Required Reading

Molecular Biology of the Cell, 6th Edition. Ed. Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter. Garland Publishers
Essential Cell Biology - 4th Edition Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander D Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter Garland Publishers
The Biology of Cancer, 2nd Edition, Robert A. Weinberg, Garland Publishers
Molecular Biology of the Gene, 7th edition, James Watson, Alexander Gann, Tania Baker, Michael Levine, Stephan Bell, Richard Losick, Stephan Harrison Pearson Cold Spring harbor Laboratory Press.
Principles of Molecular Diagnostics and Personalized Cancer Medicine, Dongfeng Tan, henry Lynch, Wolters Kluwer, Lippincott Williams&Wilkins.
The Handbook of Biomarkers, Kewal Jain, Humana Press
Translational and Experimental Clinical Research, Daniel Schuster, William Powers, Lippincott Williams&Wilkins.

Planned Learning Activities and Teaching Methods


Lectures, the topics with classroom activities (presentations and homework assignments) to consolidate and discussion

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 PRF PERFORMANCE
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE MTE * 0.20 +PRF * 0.20 + FIN* 0.60
5 RST RESIT
6 FCGR FINAL COURSE GRADE MTE * 0.20 +PRF * 0.20 +RST* 0.60


*** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

1. The learner will clearly define outlined LO1, LO2, LO4, LO5 and which will evaluate with exam.
2. The learner will recognize LO3, LO6 will evaluate with homework, prepared presentations by themselves and exam.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

yasemin.baskın@deu.edu.tr ; 0 232 412 58 01

Office Hours

Thursday11:00-12:00

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 2 30
Tutorials 15 1 15
Preparations before/after weekly lectures 15 6 90
Preparation for midterm exam 1 28 28
Preparation for final exam 1 40 40
Preparing assignments 15 6 90
Preparing presentations 10 8 80
Final 1 1 1
Midterm 1 1 1
TOTAL WORKLOAD (hours) 375

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12
LO.1555555
LO.255555555
LO.3555555
LO.45555555
LO.555555555
LO.655555555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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