COURSE UNIT TITLE

: NANOTOXICOLOGY

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
NNE 5009 NANOTOXICOLOGY ELECTIVE 3 0 0 8

Offered By

Graduate School of Natural and Applied Sciences

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR MÜNIRE NALAN TÜZMEN

Offered to

Nanoscience and Nanoengineering
Nanoscience and Nanoengineering

Course Objective

This course covers nanotoxicology, toxicological studies of carbon nanotube structures, effect-oriented physicochemical characterization of nanomaterials, exposure assessment considerations for nanoparticles, biodistribution of nanoparticles, nanoparticle interactions with biological membranes, placental biological barrier models for evaluation of nanoparticle transfer, estimating nanoparticle dose in humans, dispersion of nanoparticles in pulmonary surfactants for in vitro toxicity studies, diesel exhaust particles and fine mineral dusts, gene cellular interactions of nanomaterials, effect of carbon nanotube exposure on keratinocyte protein expression, critical issues in the evaluation of possible adverse pulmonary effects resulting from airborne nanoparticles, carbon nanotube exposure and risk for cardiovascular effects, hemostatic and thrombotic effects of particulate exposure, pulmonary and cardiovascular effects of nanoparticles, understanding the potential neurotoxicology of nanoparticles, dermal effects of nanomaterials, toxicity of nanoparticles in the eye, nanoparticle interactions with biological systems and subsequent activation of intracellular signaling mechanisms, environmental considerations, impact of nanoparticles on aquatic organisms and the environmental implications of nanomaterials.

Learning Outcomes of the Course Unit

1   To be able to explain the term of nanotoxicology
2   to be able to examine toxicological steps after exposure of nanomaterials
3   To be able to explain nanoparticle toxicity on organs
4   To be able to learn effects of nanoparticles on aquatic organisms and environment
5   To be able to follow and scrutinize the developments about nanotoxicology

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction to Nanotoxicology
2 Effect-Oriented Physicochemical Characterization of Nanomaterials
3 Exposure assessment considerations for nanoparticles and biodistribution of nanoparticles
4 Nanoparticle interactions with biological membranes, placental biological barrier models for evaluation of nanoparticle transfer and estimating nanoparticle dose in humans
5 Dispersion of nanoparticles in pulmonary surfactants for in Vitro toxicity studies, diesel exhaust particles and fine mineral dusts
6 Gene cellular interactions of nanomaterials, effects of nanoparticles on proteins, critical isues in the evaluation of possible adverse pulmonary effects resulting from airborne nanoparticles
7 Carbon nanotube exposure and risk for cardiovascular effects, hemostatic and thrombotic effects
8 Midterm exam
9 Understanding the potential neurotoxicology of nanoparticles
10 Dermal effects of nanoparticles
11 Toxicity of nanoparticles in the eye, nanoparticle interactions with biological systems and subsequent activation of intracellular signaling mechanisms
12 Environmental considerations
13 Impact of nanoparticles on aquatic organisms and environment
14 Homework presentations

Recomended or Required Reading

Hosono, H., Mishima, Y., Takezoe, H., MacKenzie, K.J.D., (eds.), Nanomaterials: From Research to Applications: Elsevier, NewYork, 2006.
Nalwa, H.(ed.),Nanostructured Materials and Nanotechnology: Elsevier, New York, 2001.
D.W.Connel, G.J. Miller, Chemistry and Ecotoxicology of Pollution, JOHN WILEY & SONS (1984)

Planned Learning Activities and Teaching Methods

Presentation, answer and question techniques, homework

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 ASG ASSIGNMENT
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE MTE * 0.20 + ASG * 0.40 + FIN * 0.40
5 RST RESIT
6 FCGR FINAL COURSE GRADE (RESIT) MTE * 0.20 + ASG * 0.40 + RST * 0.40


Further Notes About Assessment Methods

None

Assessment Criteria

The performance of students will be evaluated by the questions that will be asked in midterm (20%) and final exams (40%) and homework (40%).

Language of Instruction

Turkish

Course Policies and Rules

Attendance to at least 70% for the lectures is an essential requirement of this course and is the responsibility of the student. It is necessary that attendance to the lecture on time. Any unethical behavior that occurs either in presentations or in exams will be dealt with as outlined in school policy. You can find the undergraduate policy at http://web.deu.edu.tr/fen

Contact Details for the Lecturer(s)

nalan.tuzmen@deu.edu.tr

Office Hours

will be announced

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 14 3 42
Preparations before/after weekly lectures 14 5 70
Preparation for midterm exam 1 15 15
Preparation for final exam 1 25 25
Preparing assignments 1 35 35
Final 1 3 3
Midterm 1 3 3
TOTAL WORKLOAD (hours) 193

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7
LO.11453352
LO.21122423
LO.33415232
LO.42414111
LO.51111111