Dokuz Eylül University Information Package / Courses Catalog

Description of Individual Course Units

Course Unit Code	Course Unit Title	Type Of Course	D	U	L	ECTS
KIM 6101	METABOLIC DISMUTATION	ELECTIVE	3	0	0	7

Offered By

Graduate School of Natural and Applied Sciences

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR LEMAN TARHAN

Offered to

M.Sc. in Biochemistry
Chemistry
Ph.D in Biochemistry

Course Objective

How radicals causing toxic effect form and the dismutation reactions occuring against this toxic effect will be enlightened by discussing permanent damages, degenerative diseases and ageing periods which occur in organism in the case of imbalance between radicals and defence system although there is an antioxidant defence system on the purpose of scavenging these free radicals forming in metabolism.

Learning Outcomes of the Course Unit

1	Have a full information about free radicals,
2	Comprehend enzymatic and non-enzymatic antioxidant systems,
3	Understand scavenging mechanisms of free oxygen radicals by antioxidants,
4	Correlate between oxidative stress and diseases,
5	Examine roles of antioxidants in ageing, nutrition, diseases and therapy.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week	Subject	Description
1	Introduction to Oxygen Toxicity ve Reactive Oxygen Species
2	Free Radical Species
3	Free Radical Sources in Aerobes
4	Antioxidant and Defence Enzymes: Superoxide Dismutases (SOD)
5	Antioxidant and Defence Enzymes: Catalases
6	Antioxidant and Defence Enzymes: Glutathione Peroxidase Family
7	Glutathione Metabolism: Glutathione Peroxidase, Glutathione S-Transferase, Glutathione Reductase
8	Midterm Exam
9	Other Antioxidant Enzymes: Cytochrome c Oxidase, NADPH Peroxidase/Oxidase
10	Non-Enzymatic Antioxidant System: Ascorbic Acid, Vitamine E, - Tocopherol
11	Antioxidant Defence with Low Molecular Weight Agents: Bilirubin, Melatonin, Coenzyme Q, Dipeptides Including Histidine
12	Roles of Metal Ions in Antioxidant Defence System
13	Oxidative Stress and Diseases
14	The Roles of Antioxidants in Ageing, Nutrition, Diseases and Therapy; Presentations

Recomended or Required Reading

Textbook(s): Barry Halliwell and John M. C. Gutteridge, Free Radicals in Biology and Medicine, Oxford Science Publications, 2001.
Supplementary Book(s): Ruma Banerjee, Donald Becker, Martin Dickman, Vadim Gladyshev, Stephen Ragsdale, Redox Biochemistry, Wiley, 2007.

Planned Learning Activities and Teaching Methods

1. Presentation
2. Interactive narrative
3. Question-answer technique
4. Homework

Assessment Methods

SORTING NUMBER	SHORT CODE	LONG CODE	FORMULA
1	MTE	MIDTERM EXAM
2	ASG	ASSIGNMENT
3	PAR	PARTICIPATION
4	FIN	FINAL EXAM
5	FCG	FINAL COURSE GRADE
6	RST	RESIT
7	FCGR	FINAL COURSE GRADE (RESIT)

Further Notes About Assessment Methods

None

Assessment Criteria

Meaningful learning of the basic concepts given in presentations, association of concepts with each other, establishing the cause-result relationships and making comments by using the information available for problems and evaluating idea generation are carried out with mid-term and final exams, active participation to the lecture, homework.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

Dokuz Eylul University, Faculty of Science, Department of Chemistry
e-mail: leman.tarhan@deu.edu.tr

Office Hours

Wednesday 13.30 15.30

Work Placement(s)

None

Workload Calculation

Activities	Number	Time (hours)	Total Work Load (hours)
Lectures	13	3	39
Preparations before/after weekly lectures	13	3	39
Preparation for midterm exam	1	10	10
Preparation for final exam	1	20	20
Preparing assignments	2	15	30
Preparing presentations	2	15	30
Final	1	2	2
Midterm	1	2	2
TOTAL WORKLOAD (hours)			172

Contribution of Learning Outcomes to Programme Outcomes

PO/LO	PO.1	PO.2	PO.3	PO.4	PO.6	PO.8	PO.9	PO.10	PO.11
LO.1	5	5	5	5	5	5	5
LO.2	5	5	5	5	5	5	5		5
LO.3	5	5	5	5	5	5	5
LO.4	5	5	5	5	5	5	5
LO.5		5	5	5	5	5	5	5	5

COURSE UNIT TITLE

DEGREE PROGRAMMES

Description of Individual Course Units

Offered By

Level of Course Unit

Course Coordinator

Offered to

Course Objective

Learning Outcomes of the Course Unit

Mode of Delivery

Prerequisites and Co-requisites

Recomended Optional Programme Components

Course Contents

Recomended or Required Reading

Planned Learning Activities and Teaching Methods

Assessment Methods

Further Notes About Assessment Methods

Assessment Criteria

Language of Instruction

Course Policies and Rules

Contact Details for the Lecturer(s)

Office Hours

Work Placement(s)

Workload Calculation

Contribution of Learning Outcomes to Programme Outcomes

CONTACT INFORMATION