COURSE UNIT TITLE

: BIOCHEMICAL VIEW ON TOXICOLOGY

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
KIM 6103 BIOCHEMICAL VIEW ON TOXICOLOGY ELECTIVE 3 0 0 7

Offered By

Graduate School of Natural and Applied Sciences

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR LEMAN TARHAN

Offered to

M.Sc. in Biochemistry
Chemistry
Ph.D in Biochemistry

Course Objective

This course aims to inform exposure to the toxic agents (poisons), mechanisms of toxicity, organ toxicity and toxicity test, and factors effecting toxicity.

Learning Outcomes of the Course Unit

1   classify toxic agents and to compare exposure via inhalation, skin and gastrointestinal ways,
2   explain accumulations of xenobiotics on organs such as liver, kidney and bone and excretions of xenobiotics via renal, hepatic and exhalation,
3   learn toxicokinetic models, kinetics related to doses and kinetics in the repetition of exposure,
4   discuss mechanisms of toxicity (binding to receptors, binding to enzymes, binding other molecules, binding small molecules or ions, inhibition of energy production on a cell),
5   learn toxicity tests and discuss factors effecting toxicity from the view of chemical substances, exposure ways, type of organism and environmental factors.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 General information about toxicology and toxic agents, classification of toxic agents
2 Exposure ways to xenobiotics: exposure via inhalation, skin, and gastrointestinal
3 Accumulation on organs: Accumulation on liver and kidney, accumulation on adiposity tissues, accumulation on bone and other organs
4 Barrier systems
5 Excretion ways of xenobiotics: Renal and hepatic excretion, exhation and other excretion ways
6 Toxicokinetic models: Kinetic models, kinetics without dose, kinetics in repeated exposure
7 Mechanisms of toxicity: interaction with receptors, binding to enzymes
8 Midterm exam
9 Mechanisms of toxicity: binding to other molecules, binding to small molecules and ions, in inhibition of energy production on a cell
10 Organ toxicity: nervous system, liver, kidney
11 Organ toxicity: respiration system, blood, immun system
12 Toxicity tests
13 Factors affecting toxicity: factors related to chemicals, factors related to exposure ways, factors related to living organisms, environmental factors
14 General evaluation and presentation

Recomended or Required Reading

1. Toxicology. Edited By: Hans Marquardt, Siegfried G. Schäfer, Roger Mcclellan And Frank Welsch, Academıc Press 1999 [ISBN: 978-0-12-473270-4].
2. Toksikoloji, Nevin Vural, Ankara Üniversitesi Basımevi 2005, [I S B N : 975 - 4 8 2- 2 8 9 1].

Planned Learning Activities and Teaching Methods

The course is taught in a lecture, class presentation and discussion format. All class members are expected to attend and both the lecture and seminar hours and take part in the discussion sessions. Besides the taught lecture, group presentations are to be prepared by the groups assigned for that week and presented to open a discussion session.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 ASG ASSIGNMENT
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE MTE * 0.20 + ASG * 0.40 + FIN * 0.40
5 RST RESIT
6 FCGR FINAL COURSE GRADE (RESIT) MTE * 0.20 + ASG * 0.40 + RST * 0.40


Further Notes About Assessment Methods

None

Assessment Criteria

The students performance will be evaluated by the questions that will be asked in midterm (20%) and final exams (40%) and homework (40%).

Language of Instruction

English

Course Policies and Rules

Attendance to at least 70% for the lectures is an essential requirement of this course and is the responsibility of the student. It is necessary that attendance to the lecture on time. Any unethical behaviour that occurs either in presentations or in exams will be dealt with as outlined in school policy. You can find the undergraduate policy at http://web.deu.edu.tr/fen

Contact Details for the Lecturer(s)

Dokuz Eylul University, Faculty of Science, Department of Chemistry
e-mail: nalan.tuzmen@deu.edu.tr

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 13 3 39
Preparations before/after weekly lectures 13 3 39
Preparation for midterm exam 1 20 20
Preparation for final exam 1 30 30
Preparing assignments 1 35 35
Final 1 2 2
Midterm 1 2 2
TOTAL WORKLOAD (hours) 167

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11
LO.145511333454
LO.245511333454
LO.355543433454
LO.445511333454
LO.545544433454

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

Copyright 2015 DEÜ. BİD

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