COURSE UNIT TITLE

: OXIDATIVE STRESS AND SIGNAL TRANSDUCTION

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
KIM 6105 OXIDATIVE STRESS AND SIGNAL TRANSDUCTION ELECTIVE 3 0 0 8

Offered By

Graduate School of Natural and Applied Sciences

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR LEMAN TARHAN

Offered to

M.Sc. in Biochemistry
Chemistry
Ph.D in Biochemistry

Course Objective

How oxidative stress affects the intracellular signal transduction pathways in living systems; which stress factors play roles in activation and regulation of these pathways; relationships between signal transduction systems and ageing, inflammation, cancer and many other diseases will be discussed.

Learning Outcomes of the Course Unit

1   Contact and discuss the relationship between oxidative stress and its components inducing stress and signal transduction,
2   Examine intracellular signal transduction pathways, mechanisms and regulation steps,
3   Examine production of supporter precursors which fastly respond oxidative stress,
4   Examine the relationship between changes depend on oxidation in supporter precursors-transcription factors and gene expression,
5   Evaluate the relationship between intracellular signal transduction depend on environmental factors and cancer and other diseases.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Activation and Regulation of the Nitric Oxide-Cyclic GMP Signal Transduction Pathway by Oxidative Stress
2 Peroxynitrite and Cell Signalling
3 Nitric Oxide Signaling Through Mitochondrial Calcium Release
4 Phospholipase A2 Activation: An Early Manifestation of Oxidative Stress
5 Oxidant-Mediated Activation of Phospholipases C and D
6 The Effect of Protein Kinase C During Tumourigenesis by Oxidative Stress and Tyrosine Phosphorylation
7 Reactive Oxygen Intermediates as Signaling Molecules Regulating Leukocyte Activation
8 Midterm Exam
9 Reactive Oxygen Species as Primary Signals and Second Messengers in the Activation of Transcription Factors (SOR)
10 STAT protein (Signal Transducer and Activator of Transcription) Activation by Oxidative Stress
11 The Antioxidant System
12 Oxyradicals as Signal Transducers
13 Modulation of Smooth Muscle Cell Proliferation and Signal Transduction by Antioxidants and Oxidants
14 Induction of Gene Expression by Environmental Oxidants Associated with Inflammation, Fibrogenesis and Carcinogenesis; Presentations

Recomended or Required Reading

Textbook(s): Forman, H. J., Cadenas E., Oxidative Stress and Signal Transduction, Chapman & Hall, 1997.

Planned Learning Activities and Teaching Methods

1. Presentation
2. Interactive narrative
3. Question-answer technique
4. Homework

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 ASG ASSIGNMENT
3 PAR PARTICIPATION
4 FIN FINAL EXAM
5 FCG FINAL COURSE GRADE
6 RST RESIT
7 FCGR FINAL COURSE GRADE (RESIT)


Further Notes About Assessment Methods

None

Assessment Criteria

Meaningful learning of the basic concepts given in presentations, association of concepts with each other, establishing the cause-result relationships and making comments by using the information available for problems and evaluating idea generation are carried out with mid-term and final exams, active participation to the lecture, homework.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

leman.tarhan@hotmail.com

Office Hours

Wednesday 13.30-15.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 13 3 39
Preparations before/after weekly lectures 13 3 39
Preparation for midterm exam 1 20 20
Preparation for final exam 1 30 30
Preparing assignments 2 15 30
Preparing presentations 2 20 40
Final 1 2 2
Midterm 1 2 2
TOTAL WORKLOAD (hours) 202

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11
LO.15555555
LO.255555555
LO.35555555
LO.45555555
LO.555555555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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