COURSE UNIT TITLE

: PROGRAMMED CELL DEATH: APOPTOSIS

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
KIM 5114 PROGRAMMED CELL DEATH: APOPTOSIS ELECTIVE 3 0 0 8

Offered By

Graduate School of Natural and Applied Sciences

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR LEMAN TARHAN

Offered to

M.Sc. in Biochemistry
Chemistry
Ph.D in Biochemistry

Course Objective

Within the context of this course, it is aimed to discuss the topics of cell proliferation and death, programmed cell death apoptosis and its induction factors, the control pathways, morphological and biochemical changes, its relationship with diseases as well as other alternative cell death and necrosis in autophagy.

Learning Outcomes of the Course Unit

1   Know cell proliferation and death.
2   Produce an idea about programmed cell deaths.
3   Comprehend apoptosis and its induction factors, the control mechanisms and morphological-biochemical changes observed during apoptotic cell death.
4   Produce an idea about the differences of programmed cell deaths.
5   Gain knowledge about techniques used to characterize apoptotic cell death.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Cell Proliferation and Introduction to Cell Death 1.1. Structure and function of eukaryotic cell and its nuclei 1.2. Effective mechanisms on cell proliferation and death
2 Programme Cell Death Apoptosis and its Regulation 2.1. Environmental factors inducing apoptotic cell death 2.2. The characteristic morphological changes observed in apoptotic cell death 2.3. The characteristic biochemical changes observed in apoptotic cell death 2.4. Extrinsic pathway of apoptotic cell death and its regulation 2.5. Intrinsic pathway of apoptotic cell death and its regulation
3 The caspase family in apoptotic cell death 3.1. Participation of caspases to apoptosis 3.2. Classification and structure of caspases 3.3. Activation of caspases 3.4. Inhibition of caspases 3.5. Substrates of caspases
4 Regulation of apoptosis by Bcl-2 family proteins 4.1. Discovery of Bcl-2 gene and its antiapoptotic function 4.2. Bcl-2 family proteins and their biochemical functions 4.3. Regulation of Bcl-2 family members
5 Mitochondria in Apoptotic cell death 5.1. Mitochondrial contribution to cell death 5.2. Cytochrome c 5.3. Mitochondrial caspases 5.4. Heat shock proteins 5.5. Apoptosis inducing factors 5.6. Endonuclease G 5.7. SMAC/DIABLO 5.8. Some metabolic changes occurred by increased permeability of the mitochondrial membrane
6 Apoptotic cell death by death receptors 6.1. Death receptor superfamily 6.2. Ligands of TNF receptor superfamily 6.3. Adaptor proteins 6.4. Ölüm reseptörleri indüklü hücre ölümünün regülasyonu/ the regulation of cell death induced by Death receptors 6.5. Diseases related death receptor signaling pathways
7 Signal transduction in Apoptotic cell death 7.1. Signal transduction pathway of Jnk, calcium, wnt, NF-KB, Ras and p53 in apoptosis
8 Midterm Exam
9 MAPKS and apoptosis
10 STATs and apoptosis
11 Autophagic and necrotic cell death
12 Alternative Programmed Cell Deaths
13 Techniques used to characterize the apoptotic cell death
14 Presentations

Recomended or Required Reading

Textbook(s): Micheal D. Jacobson, Apoptosis: The Molecular Biology of Programmed Cell Death, Oxford University Press, 2002.
Supplementary Book(s): Lawrance M. Schwartz, Apoptosis, Academic Press, 2001.

Planned Learning Activities and Teaching Methods

1. Presentation
2. Interactive narrative
3. Question-answer technique
4. Homework

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 ASG ASSIGNMENT
3 PAR PARTICIPATION
4 FIN FINAL EXAM
5 FCG FINAL COURSE GRADE
6 RST RESIT
7 FCGR FINAL COURSE GRADE (RESIT)


Further Notes About Assessment Methods

None

Assessment Criteria

Meaningful learning of the basic concepts given in presentations, association of concepts with each other, establishing the cause-result relationships and making comments by using the information available for problems and evaluating idea generation are carried out with mid-term and final exams, active participation to the lecture, homework.

Language of Instruction

English

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

Dokuz Eylul University, Faculty of Science, Department of Chemistry
e-mail: leman.tarhan@deu.edu.tr

Office Hours

Wednesday 13.30 15.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 13 3 39
Preparations before/after weekly lectures 13 3 39
Preparation for midterm exam 1 20 20
Preparation for final exam 1 30 30
Preparing assignments 2 15 30
Preparing presentations 2 20 40
Final 1 2 2
Midterm 1 2 2
TOTAL WORKLOAD (hours) 202

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11
LO.155545555443
LO.255545545443
LO.354445545443
LO.455545545443
LO.555545545433

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

Copyright 2015 DEÜ. BİD

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