COURSE UNIT TITLE

: MEMBRANE RECEPTORS AND FORMATION SYSTEMS

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
KIM 6106 MEMBRANE RECEPTORS AND FORMATION SYSTEMS ELECTIVE 3 0 0 7

Offered By

Graduate School of Natural and Applied Sciences

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR LEMAN TARHAN

Offered to

M.Sc. in Biochemistry
Chemistry
Ph.D in Biochemistry

Course Objective

Within the context of this course, it is aimed that the receptor theory, characterization methods of membrane receptors, localization of receptors in tissue and cells, ligand binding kinetic, cell membrane receptors, intracellular and intercellular signal transduction will investigated in detail.

Learning Outcomes of the Course Unit

1   Produce an ideas about receptor theory and characterization methods of membrane receptors,
2   Produce an idea and develop a strategy about ligand binding kinetic.
3   Produce an idea about the cell membrane receptors.
4   Gain knowledge about intracellular and intercellular signal transduction.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction
2 Receptor theory: Occupation theory, Determination of ligand-receptor involvement, Speed theory, Allozyme hypothesis
3 Methods for Characterization of Membrane Receptors
4 Determination of dissociation constant of antagonists, Determination of the its effectiveness
5 Stereoselectivity and Stereoisomer Effective Components on the Interactions with Membrane Receptors Ligands
6 Localization of receptors in the tissues and cells
7 Ligand Binding Kinetics: Saturation experiments; Scatchard-curve; Hill-curve
8 Midterm Exam
9 Ligand Binding Kinetics: The inhibition effect; Eady-Hofstee curve; Experimental kinetic applications
10 Cell Membrane Receptors: Structure of cell membrane; Phospholipid-glycolipid; Stern, Structure models of biological membranes, Lipids and membrane receptors, Interactions, Biosynthesis of membrane receptors; The cage movement of membrane receptors; Down Regulation
11 Determination of molecular structure of the receptor: Solubilization of membrane receptors in natural conformation, The interaction of membrane lipids with detergents; Isolation of membrane receptors, Membrane receptors and antibodies
12 Intracellular Signal Transduction: Basic Principles of Signal Conduction, G-proteins, c-Nükelotid system; Guanilatsiclase, Catabolism of c-nucleotides, c-nucleotides connection between cells, Ca + + system; phosphoinositide system
13 Intercellular Signal Transduction: Arachidonic acid metabolism
14 Presentations

Recomended or Required Reading

Textbook(s): Repke H., Liebmann C. Membranreseptoren und Ihre Effektorsysteme, VCH Verlagsgesellschaft mbH, 1988.

Planned Learning Activities and Teaching Methods

1. Presentation
2. Interactive narrative
3. Question-answer technique
4. Homework

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 ASG ASSIGNMENT
3 PAR PARTICIPATION
4 FIN FINAL EXAM
5 FCG FINAL COURSE GRADE
6 RST RESIT
7 FCGR FINAL COURSE GRADE (RESIT)


Further Notes About Assessment Methods

None

Assessment Criteria

Meaningful learning of the basic concepts given in presentations, association of concepts with each other, establishing the cause-result relationships and making comments by using the information available for problems and evaluating idea generation are carried out with mid-term and final exams, active participation to the lecture, homework.

Language of Instruction

English

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

leman.tarhan@deu.edu.tr

Office Hours

Wednesday 13.30 15.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 13 3 39
Preparations before/after weekly lectures 13 3 39
Preparation for midterm exam 1 10 10
Preparation for final exam 1 20 20
Preparing assignments 2 15 30
Preparing presentations 2 15 30
Final 1 2 2
Midterm 1 2 2
TOTAL WORKLOAD (hours) 172

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11
LO.144554454
LO.244554454
LO.344554454
LO.444554454

CONTACT INFORMATION
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