COURSE UNIT TITLE

: INTRODUCTION TO METASTASIS BIOLOGY

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
ONK 5050 INTRODUCTION TO METASTASIS BIOLOGY ELECTIVE 2 0 0 4

Offered By

Basic Oncology

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR SAFIYE AKTAŞ

Offered to

Basic Oncology

Course Objective

The aim of this course is to understand the biology of cancer, angiogenesis, invasion and metastasis and their clinical view.

Learning Outcomes of the Course Unit

1   Capable of understanding molecular biologic properties of tumors; nature of metastasis.
2   Be able to explain cancer from molecule to cell and from cell to tissue
3   Be able to know cell adhesion molecules and their roles in cancer
4   Be able to learn role of angiogenesis and lymphangiogenesis in cancer.
5   Be able to understand stages of metastasis and metastasis related genes.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 The concept of metastasis
2 Tumor Progression and genetic instability
3 Origins of Metastatic Tumor cells
4 Genetic control of metastasis (differences from tumorogenesis, tumor suppressor genes)
5 Metastatic cascade
6 Tumor Microenvironment (detection of metastatic potential and metastatic site)
7 Proteases in tumor cell invasion
8 Tumor cell motility
9 Tumor basement invasion and initiating tumor cell migration
10 Cell to cell adhesion and metastasis suppressors
11 Cell Matrix Interactions and Tumor Cell Migration
12 The role of integrins in tumor migration
13 Cell Migration
14 Methods in evaluating tumor progression and metastasis (Invasion, metastasis experiments, models, Microarrays )
15 Final exam

Recomended or Required Reading

1. Diagnostic Approach to Clinical Oncology Mario W. Fiorentino PICCIN 1999
2. Molecular Biology in Cancer Medicine. Razelle Kurzrock, Moshe Talpaz, Martin Dunitz 1995.
3. AJCC Cancer Staging Handbook.Irvin D. Fleming. Lippincott Willams & Wilkins 1998
4. Manual of Clinical Oncology. D.K. Hossfeld, C.D. Sherman, R.R. Love, F.X. Bosch Springer- Verlag, 1990 Fith Edition.
5. Pathologic Basis of Disease. Vinay Kumar, Abul K. Abbas, Nelson Fausto, Elsevier Saunderss, 2005 Seventh Edition
6. Molecular Mechanism of Cancer. Georg F. Weber, Springer 2007
7. The Biology of Cancer Robert A. Weinberg, Gariand Science 2007

Planned Learning Activities and Teaching Methods

Theoretical Lectures, Giving a homework, Working for exams, Reading practices

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 FIN FINAL EXAM
3 FCG FINAL COURSE GRADE MTE * 0.40 + FIN* 0.60
4 RST RESIT
5 FCGR FINAL COURSE GRADE MTE * 0.40 + RST* 0.60


Further Notes About Assessment Methods

None

Assessment Criteria

Learning outcomes will be assessed with classical questions of final exams. The homework on the topic of mechanisms of metastasis of lung cancer, colorectal cancer, breast cancer and prostat cancer will help in evaluating the learner understood the topics or not.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

zekiye.altun@deu.edu.tr 0 232 4128204/5801

Office Hours

on Tuesday at: 13.30-16.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 14 2 28
Preparations before/after weekly lectures 15 2 30
Preparing assignments 1 20 20
Preparation for final exam 1 20 20
Final 1 2 2
TOTAL WORKLOAD (hours) 100

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10
LO.155
LO.255
LO.355
LO.455
LO.555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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