COURSE UNIT TITLE

: MUTAGENITY APPLICATIONS IN CANCER

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
ONK 5052 MUTAGENITY APPLICATIONS IN CANCER ELECTIVE 2 0 0 3

Offered By

Basic Oncology

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR ZEKIYE SULTAN ALTUN

Offered to

Basic Oncology

Course Objective

The aim of this course is to understand the effective in the etiology of cancer and carcinogenesis / can be viral, chemical, and physical agents and mutagenic effects of mutagenic testing methods to understand the mechanisms and roles.

Learning Outcomes of the Course Unit

1   Capable of understanding mutagenity concepts in carcinogenesis.
2   Be able to explain and learn the mutagenic effects of chemical agents that are effective in cancer development and to its role in the development of cancer.
3   Be able to know bacterial revers mutation test, mammalian chromosome aberration test, mammalian erythrocyte micronucleus tests to explain the working mechanisms
4   Be able to know and learn role of Mikronucleasyon in vitro test, the three-dimensional to know and learn about the role of genotoxic test and comet assay in mutagenesis.
5   Be able to understand to practice and learn new mutagenicity appplications Role in cancer research.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 The concept of mutagens in carsinogenic development
2 Mutagenic effects of chemical agents that are effective in the development of cancer
3 Bacterial revers mutation test (Ames test)
4 Mamalian kromosom aberation test
5 Mamalian cell gene mutation test
6 In vitro memeli Mamalian cell micronukleus test
7 Mamalian erythrocyte micronukleus test
8 Presentaions of homeworks
9 Mammalian bone marrow chromosome aberration test
10 Transgenic rodent somatic and germline cell gene mutation tests
11 In-vitro micronukleus test
12 Three dimensional testing genotoxic
13 Comet Assay
14 New Mutagenicity applications in cancer research
15 Final Exam

Recomended or Required Reading

1. Diagnostic Approach to Clinical Oncology Mario W. Fiorentino PICCIN 1999
2. Molecular Biology in Cancer Medicine. Razelle Kurzrock, Moshe Talpaz, Martin Dunitz 1995.
3. AJCC Cancer Staging Handbook.Irvin D. Fleming. Lippincott Willams & Wilkins 1998
4. Manual of Clinical Oncology. D.K. Hossfeld, C.D. Sherman, R.R. Love, F.X. Bosch Springer- Verlag, 1990 Fith Edition.
5. Pathologic Basis of Disease. Vinay Kumar, Abul K. Abbas, Nelson Fausto, Elsevier Saunderss, 2005 Seventh Edition
6. Molecular Mechanism of Cancer. Georg F. Weber, Springer 2007
7. The Biology of Cancer Robert A. Weinberg, Gariand Science 2007

Planned Learning Activities and Teaching Methods

Theoretical Lectures, Giving a homework, Working for exams, Reading practices .

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 PRF PERFORMANCE
2 FIN FINAL EXAM
3 FCG FINAL COURSE GRADE PRF * 0.40+ FIN* 0.60
4 RST RESIT
5 FCGR FINAL COURSE GRADE PRF * 0.40+ RST* 0.60


Further Notes About Assessment Methods

None

Assessment Criteria

Learning outcomes will be assessed with classical questions of final exams. Mutagenicity test applications on a special assignment will be enhanced by special types of cancers.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

zekiye.altun@deu.edu.tr 0 232 4128204/5801

Office Hours

on Tuesday at: 13.30-16.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 14 2 28
Preparations before/after weekly lectures 15 1 15
Preparation for final exam 1 10 10
Preparing assignments 1 20 20
Final 1 2 2
TOTAL WORKLOAD (hours) 75

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10
LO.155
LO.255
LO.355
LO.455
LO.555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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