Dokuz Eylül University Information Package / Courses Catalog

Description of Individual Course Units

Course Unit Code	Course Unit Title	Type Of Course	D	U	L	ECTS
ONK 5042	CANCER BIOLOGY AND GENETICS	COMPULSORY	1	0	0	3

Offered By

Basic Oncology

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR YASEMIN BASKIN

Offered to

Translational Oncology
Basic Oncology

Course Objective

The aim of this course, the emergence of cancer as a clinical process is the regaining of the basic information about the biological and genetic processes.

Learning Outcomes of the Course Unit

1	The basic mechanisms of cancer cell biology can be expressed with the main lines
2	Be able to know the basic processes in the genetics of cancer cells
3	Be able to know the differences of cancer cell biology and genetic processes than normal cells
4	Be able to discuss the function of oncogenes and tumor suppressor genes in carcinogenesis
5	Be able to Interpret the multistep process of cancer
6	Be able to critically evaluates the multistep carcinogenesis

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week	Subject	Description
1	Introduction to cell biology (cancer burden, oncogenesis and cell cycle)
2	Main Macromolecules (genes and proteins)
3	Fundamental processes of cell genetics (replication, transcription, translation, DNA repair)
4	Cell cycle and its control
5	Apoptosis and regulation
6	Structure and function of oncogenes (ras, myc)
7	Effective mechanisms for the regulation of tumor suppressor genes and their functions RB1, WT1, MEN1, FAP1, p53, APC
8	Chromosomal stability, chromosomal translocations, Telomeres and cancer
9	Transcription factors in oncogenesis, growth factor receptors and signal transduction,
10	The nuclear receptor superfamily
11	GTP-binding proteins, protein-protein interactions
12	Cytoplasmic protein kinases and phosphatases, secondary messengers
13	Adhesion molecules and cell matrix
14	Invasion and metastasis, angiogenesis in tumors and molecular mediators of angiogenesis
15	Relationships and mechanisms of antineoplastic drugs

Recomended or Required Reading

Textbook(s): Molecular Mechanism of Cancer. Georg F. Weber, Springer,2007.
Pathologic Basis of Disease. Vinay Kumar, Abul K. Abbas, Nelson Fausto, Elsevier Saunderss, 2005 Seventh Edition;
The Biology of Cancer Robert A. Weinberg, Gariand Science 2007;
Moleküler Biyoloji, Editör: Ahmet Yıldırım Nobel Yayın Dağıtım; Ankara, 2010,
Referanslar:
Materials: Pubmed

Planned Learning Activities and Teaching Methods

Theoretical Lectures, the topics in-class activities (presentations and assignments) to consolidate and discussion

Assessment Methods

SORTING NUMBER	SHORT CODE	LONG CODE	FORMULA
1	MTE	MIDTERM EXAM
2	PRF	PERFORMANCE
3	FIN	FINAL EXAM
4	FCG	FINAL COURSE GRADE	MTE * 0.20 +PRF * 0.20 + FIN* 0.60
5	RST	RESIT
6	FCGR	FINAL COURSE GRADE	MTE * 0.20 +PRF * 0.20 +RST* 0.60

Further Notes About Assessment Methods

None

Assessment Criteria

1. The learner will clearly define outlined LO1,LO2, LO3 which will evaluate with exam.
2. The learner will recognize LO4, LO5, LO5, will evaluate with homework, prepared presentations by themselves and exam.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

yasemin.baskin@deu.edu.tr 0 232 4125890/5801

Office Hours

on Monday at: 13.30-16.30

Work Placement(s)

None

Workload Calculation

Activities	Number	Time (hours)	Total Work Load (hours)
Lectures	15	1	15
Preparation for midterm exam	1	12	12
Preparation for final exam	1	20	20
Preparing assignments	1	16	16
Preparing presentations	1	10	10
Final	1	1	1
Midterm	1	1	1
TOTAL WORKLOAD (hours)			75

Contribution of Learning Outcomes to Programme Outcomes

PO/LO	PO.1	PO.2	PO.3	PO.4	PO.5	PO.6	PO.7	PO.8	PO.9	PO.10
LO.1	5	5			5	5		5	5
LO.2	5	5			5	5		5	5	5
LO.3	5	5			5	5		5	5	5
LO.4	5		5	5	5			5
LO.5	5	5			5	5		5	5
LO.6	5				5	5	5		5	5

COURSE UNIT TITLE

DEGREE PROGRAMMES

Description of Individual Course Units

Offered By

Level of Course Unit

Course Coordinator

Offered to

Course Objective

Learning Outcomes of the Course Unit

Mode of Delivery

Prerequisites and Co-requisites

Recomended Optional Programme Components

Course Contents

Recomended or Required Reading

Planned Learning Activities and Teaching Methods

Assessment Methods

Further Notes About Assessment Methods

Assessment Criteria

Language of Instruction

Course Policies and Rules

Contact Details for the Lecturer(s)

Office Hours

Work Placement(s)

Workload Calculation

Contribution of Learning Outcomes to Programme Outcomes

CONTACT INFORMATION