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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS PER 5003 PHYSIOPATHOLOGY OF THE CARDIOPULMONARY BYPASS AND CIRCULATION SYSTEM COMPULSORY 1 2 0 5

Offered By

Perfusion Techniques

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR ERDEM ERINÇ SILISTRELI

Offered to

Perfusion Techniques

Course Objective

Theperfusion systemused duringopen heart surgeryrelated tophysiological changesand theirpathophysiology; cardiovascular systemfurtherhemodynamic changes,pressureregulationandflow, complementarysystem,inflammatory system, endocrine system,coagulation systemandand theirpathophysiologyinvolvingcourse.

Learning Outcomes of the Course Unit

1   obtains anatomic and physiological basis for perfusion applications in cardiovascular procedures 2   providesterminologicaldominance 3   explains cardiovascular physiological components 4   explains cardiovascular physiological components 5   Understands Deviations in Complementsystem and theinflammatory system 6   Can understand the Pathophysiology of Endocrine system 7   Can speculate about preventation of disorders inthe coagulation system

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 Cardiovascularanatomy(mediastinum and heart,the action potential, contraction mechanism 2 cardiacarteries, veins and microcirculation), transmission system, major arteriesand veins, cardiacembryology,vascularembryology,cerebral circulation, cerebral bloodflow 3 Cardiovascular physiology, cardiovascularhemodynamics 4 Pulmonarycirculation, ventilation,oxygenation, respiration,pulmonary hypertension 5 Coronarycirculation, flowdeterminants ofcoronary bloodmetabolites,determinants ofO2 deliverytomyocardium, O2consumptiondeterminants 6 Myocardialphysiology: 7 Hematology:blood group, blood cells,plasma proteins,blood count,bloodsausagesolutions, complamentarytherapy,crossmatch, Transfuseproducts (RBC, FFP, platelets, Cryoprecipitat) and transfusiontechniques. 8 Midterm Exam 9 Coagulation systemsandmanagement:physiology andhemoztazisof coagulation, plateletformationand degradation, platelet activation, coagulation cascade, the fibrinolytic system, coagulopathy,heparinresistance. 10 Myocardialperformance:Starlinglawof the heart, pressure-volume curves, atrial and ventricularcycle, heart valves,cardiac outputdetermination 11 Interconnectionofpulmonaryand systemic circulation, cardiac and venousvalveseffect onbloodflow; hemodynamics: Arteries,arterioles,capillaries, venules, veins 12 Determinantsof cardiac output: Strokevolume, vascular resistance, heart rate,filling pressure; complianceresistance. 13 Renal Physiology: water balance,electrolytethe balance, plasma volume,acid-base balance, osmolaritybalance, extraction, hormonesecretion, glomerular filtration, tubularreabsorption, tubular secretion, endocrine regulation:the renin-angiotensin-aldosterone system, ACE inhibitors,erythropoietinRBCformation 14 Endocrine system,inflammatory system, the complement system, immune system

Recomended or Required Reading

Richard E. Klabunde, Cardiovascular Physiology Concepts; William R. Milnor, Cardiovascular Physiology; John B. Wes, Respiratory Physiology: The Essentials.

Planned Learning Activities and Teaching Methods

PowerPoint presentationsand oral.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 MTE MIDTERM EXAM 2 FIN FINAL EXAM 3 FCG FINAL COURSE GRADE MTE * 0.40 + FIN* 0.60 4 RST RESIT 5 FCGR FINAL COURSE GRADE MTE * 0.40 + RST* 0.60

Further Notes About Assessment Methods

None

Assessment Criteria

Midterm exams,homeworkissues, final exam.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

To be announced.

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 14 1 14 Tutorials 14 2 28 Preparations before/after weekly lectures 14 3 42 Preparation for midterm exam 1 17 17 Preparation for final exam 1 20 20 Final 1 2 2 Midterm 1 2 2 TOTAL WORKLOAD (hours) 125

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 PO.8 PO.9 PO.10 LO.1 5 4 LO.2 LO.3 3 3 LO.4 4 4 LO.5 5 3 LO.6 4 LO.7 5