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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS BMT 0607 BIOMATERIALS-TISSUE INTERACTIONS ELECTIVE 3 0 0 6

Offered By

Graduate School of Natural and Applied Sciences

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSISTANT PROFESSOR AYLIN ŞENDEMIR ÜRKMEZ

Offered to

Industrial Ph.D. Program In Advanced Biomedical Technologies Industrial Ph.D. Program In Advanced Biomedical Technologies

Course Objective

To teach the physical and biological principles that serve as the scientific basis for understanding the interactions of biological molecules and cells with biomaterials employed for the fabrication of permanent implantable prostheses and as matrices for tissue engineering.

Learning Outcomes of the Course Unit

1   Learning the basic definitions of unit cell processes, biocompatibility, foreign body reactions, tissue and biomaterial interactions 2   Learning the main problems faced in biomaterials applications, basis of biomaterial selection parameters, production and evaluation methods and clinical applications 3   Improving the research, analysis, comparison and criticizing capabilities of the students in current applications of biomaterials, and enhancing their ability to propose alternative solutions 4   Recognizing the interdisciplinary approach among the clinic and research activities in the area, and analyzing the sample solution producing approaches between medical doctors, life scientists and engineers

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 Biocompatibility, hemacompatibility, foreign body reactions to biomaterials 2 Unit cell processes 3 Problems with metallic alloys as biomaterials (stainless steel, titanium, cobalt-cromium) 4 Corrosion in the body 5 Implant toxicity 6 Molecular and cellular interactions between standardized biomaterials surfaces and model biological environments. 7 Midterm 8 Problems with ceramic implants and coatings 9 Dental materials 10 Problems with polymer implants 11 Heart valve substitutes 12 Problems with biodegradation and biodegradable implants 13 Problems with Tissue engineering 14 Presentation and discussion of term projects

Recomended or Required Reading

1. Jozef A. Helsen, Yannis Missirlis, Biomaterials: A Tantalus Experience , Springer 2010. 2. Scientific articles provided during the semester

Planned Learning Activities and Teaching Methods

Exams and project

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 MTE MIDTERM EXAM 2 ASG ASSIGNMENT 3 FIN FINAL EXAM 4 FCG FINAL COURSE GRADE MTE * 0.20 + ASG * 0.20 + FIN * 0.60 5 RST RESIT 6 FCGR FINAL COURSE GRADE (RESIT) MTE * 0.20 + ASG * 0.20 + RST * 0.60 *** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

English

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

To be announced.

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 14 3 42 Reading 14 3 42 Preparation for midterm exam 1 10 10 Preparation for final exam 1 20 20 Design Project 1 30 30 Final 1 2 2 Midterm 1 2 2 TOTAL WORKLOAD (hours) 148

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 PO.8 PO.9 PO.10 LO.1 2 3 5 4 LO.2 1 4 LO.3 4 3 LO.4