COURSE UNIT TITLE

: NUTRITION GENOMICS AND CANCER

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
ONK 6104 NUTRITION GENOMICS AND CANCER ELECTIVE 1 0 0 3

Offered By

Basic Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSISTANT PROFESSOR RÜKSAN ÇEHRELI

Offered to

Basic Oncology

Course Objective

Examination of the relationship between cancer and moleculer nutrition in the process of carcinogenesis .The particularly targeted the investigation and discuss of multidisciplinary research topics context of relations cancer, and genomics ,nutrigenetics nutrigenomics, epigenomics
Nutritional biochemistry is concerned with the properties of nutrients and other dietary constituents and the study of their biochemical, metabolic, physiological and epigenetic functions. An important focus is the application of knowledge in tumour biology and chemoprevention to the synergistic relationships among diet,spesific nutrients
To provide experience in issues related to in vitro conditions of chemoprevention studies . the students Issues in this course about of the project and scientific studies was intended to ensure the adaptation.

Learning Outcomes of the Course Unit

1   1.Capable of outline the relationship between cancer and the molecular nutrition can express (knowledge).
2   2.Be able to recognize and understand the relationship between Cancer and genetics, nutrigenetics, nutrigenomics , epigenetics ,
3   3.Be able to recognize and understand the relationship between cancer with genome-nutrient interactions including the role of nutrients and dietary components in regulation of genome structure, expression and stability and the role of genetic variation on individual nutrient requirements
4   4.Be able to identify of tumor biology and nutrient relations
5   5.Be able to identify relationships of epigenetics among diet ,metabolism,DNA and protein methylation and gene expression during development cancer
6   6.Be able to identify relationships of Nutritional metabolomics with includes regulation of metabolic pathways by nutrients and other food components and the establishment of analytical methods
7   7.Be able to research and inquire about the work of cancer and moleculer nutrition (analyses)

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Molecular nutrition and tumor biology overview Nutritional metabolomics: Nutrients and metabolic pathways affecting tumor cell activity as
2 Inflammation cancer and nutrients Tumour biology and bioactive foods
3 Epigenetics cancer and diet Gastrointestinal cancers and gen nutrient relations
4 Nutritional epigenomics The moleculer nutrition approaches to breast, ovarian, prostate cancer chemoprevention
5 Nutrigenetic ,nutrigenomics and cancer The future of ıntegrative medicine and Cancer Treatments and spesific bioactive compounds of food in clinic and preclinical studies
6 Energy balances ,epiobecigenetic genes,metabolomics EXAM
7 Apoptosis and nutrients
8 Angiogenesis and nutrients
9 Tumour cell activities and nutritional immunology
10 cancer cells with relations Nutritional biochemistry, metabolic, physiological, epigenetic functions and nutrients

Recomended or Required Reading

Nutrigenetics and Nutrigenomics . A.P.Simopoulos ,JM.Ordovas . Karger 2010 ,
Cancer and Nutrition , Elsevier Saunders,2012
Advances in Nutrition and Cancer .Vincenzo Zappia Salvatore Panico Gian Luigi Russo Editors. Springer-Verlag Berlin Heidelberg 2014 ISBN 978-3-642-38007-5 (eBook)
References
Akdeniz Usulü beslenme Uşşak Tif Matbaacılık 2009 (Akdeniz usulü Beslenme ve kanser Bölüm yazarı: Rüksan Çehreli ),
Moleculer Nutrition and cancer . R.Çehreli . Klinik Aktüel Tıp Onkoloji Özel Sayısı ).2006 .11( 10)
Epigenetics cancer and diet R Çehreli .Türkiye Klinikleri suppl..2015

Nutriomes and personalised nutrition for DNA damage prevention, telomere integrity maintenance and cancer growth control. Fenech MF. Cancer Treat Res. 2014;159:427-41

Targeting the epigenome with bioactive food components for cancer prevention.Ong TP, Moreno FS, Ross SA. J Nutrigenet Nutrigenomics. 2011;4(5):275-92.

Epigenetic diet: impact on the epigenome and cancer. Hardy TM, Tollefsbol TO. Epigenomics. 2011 Aug;3(4):503-18

The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases: a review. Vahid F, Zand H, Nosrat-Mirshekarlou E, Najafi R, Hekmatdoost A.
Gene. 2015 May 10;562(1):8-15

Planned Learning Activities and Teaching Methods

Theoretical and applied Lectures, in vivo and in vitro conditions in the laboratory observation of the ongoing studies on cancer and nutrient relations presentation regarding relations between cancer and molecular nutrition by students, giving a homework.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 PRF PERFORMANCE
2 FIN FINAL EXAM
3 FCG FINAL COURSE GRADE PRF * 0.40 + FIN*0.60
4 RST RESIT
5 FCGR FINAL COURSE GRADE (RESIT) PRF * 0.40 + FCGR*0.60


*** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

1. The learner will clearly define outlined cancer and moleculer nutrition which will evaluate with presentations prepared by themselves, homework

2. The learner will assignments related to the cancer and genomic,nutrigenetics,nutrigenomics making the presentation and homework , exam

3. The learner will assignments related to the tumour biology and nutrients, making the presentation,homework, exam

4. The learner will recognize cancer and moleculer epidemiology , nutritional epidemiology studies; will evaluate with homework, prepared presentations by themselves and exam

5. The learner will recognize cancer and moleculer nutrition studies; will evaluate with homework, prepared presentations by themselves and exam

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

ruksan.cehreli@deu.edu.tr,
tel: 4124804

Office Hours

Friday : 14.00 16.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 1 15
Preparation for final exam 1 36 36
Preparing assignments 1 21 21
Final 1 3 3
TOTAL WORKLOAD (hours) 75

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11
LO.155555
LO.255555
LO.355555
LO.455555
LO.555555
LO.655555
LO.755555