COURSE UNIT TITLE

: TUMOR MICROENVIRENMENT

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
TRO 6001 TUMOR MICROENVIRENMENT ELECTIVE 1 0 0 6

Offered By

Translational Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR YASEMIN BAŞBINAR

Offered to

Translational Oncology

Course Objective

Tumour micro-environment is a target for new therapeutic strategies which plays an important role in the processes of tumour formation, growth and metastasis. In this context, hypoxia and cancer, tumour angiogenesis, tumour immune system relationships, inflammation and cancer, tumour-stroma relationship, extracellular matrix , micro-environmental effects in invasion and metastasis, cancer stem cell and mesenchymal stem cell relationships, tumour growth and microenvironment, The role of the microenvironment in drug resistant, microenvironment as a new therapeutic targets will be discussed.

Learning Outcomes of the Course Unit

1   Be able to recognize and comprehend the general outline of Tumor-stroma relationship
2   Be able to know the tumour microenvironment in cancer.
3   Be able to know the relationship between hypoxia and cancer
4   Be able to recognize and comprehend the tumour angiogenesis, tumour immune system relationships, inflammation and cancer, tumour-stroma relationship, extracellular matrix , micro-environmental effects in invasion and metastasis.
5   Be able to refers to , cancer stem cell and mesenchymal stem cell relationships, tumour growth and microenvironment, The role of the microenvironment in drug resistant.
6   Be able to know microenvironment as a new therapeutic target.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Presentation of course and Concepts
2 Hypoxia and cancer,
3 Tumor angiogenesis,
4 Tumor immune system relations,
5 Inflammation and cancer
6 Relationship of tumor-stroma 1
7 Relationship of tumor-stroma 2
8 The extracellular matrix
9 Micro-environmental effects in invasion and metastasis
10 Cancer stem cell and mesenchymal stem cell relations
11 Tumor growth and microenvironment
12 The role of the microenvironment in the drug resistance
13 New drug target in the microenvironment
14 New drug target in the microenvironment 2
15 Debates

Recomended or Required Reading

Molecular Biology of the Cell, 6th Edition. Ed. Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter. Garland Publishers
Essential Cell Biology - 4th Edition Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander D Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter Garland Publishers
The Biology of Cancer, 2nd Edition, Robert A. Weinberg, Garland Publishers
Molecular Biology of the Gene, 7th edition, James Watson, Alexander Gann, Tania Baker, Michael Levine, Stephan Bell, Richard Losick, Stephan Harrison Pearson Cold Spring harbor Laboratory Press.
Principles of Molecular Diagnostics and Personalized Cancer Medicine, Dongfeng Tan, henry Lynch, Wolters Kluwer, Lippincott Williams&Wilkins.
The Handbook of Biomarkers, Kewal Jain, Humana Press
Translational and Experimental Clinical Research, Daniel Schuster, William Powers, Lippincott Williams&Wilkins.

Planned Learning Activities and Teaching Methods

Lectures, the topics with classroom activities (presentations and homework assignments) to consolidate and discussion

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 PRF PERFORMANCE
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE MTE * 0.20 +PRF * 0.20 + FIN* 0.60
5 RST RESIT
6 FCGR FINAL COURSE GRADE MTE * 0.20 +PRF * 0.20 +RST* 0.60


*** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

1. The learner will clearly define outlined LO1, LO2, LO3, LO4 which will evaluate with exam.
2. The learner will recognize LO5, LO6 will evaluate with homework, prepared presentations by themselves and exam.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

yasemin.baskin@deu.edu.tr ; 0 232 412 58 01

Office Hours

Thursday 13:00-14:00

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 1 15
Preparations before/after weekly lectures 15 5 75
Preparation for midterm exam 1 8 8
Preparation for final exam 1 10 10
Preparing assignments 5 4 20
Preparing presentations 2 10 20
Final 1 1 1
Midterm 1 1 1
TOTAL WORKLOAD (hours) 150

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12
LO.155555
LO.255555
LO.3555555
LO.45555555
LO.555555555
LO.655555555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

Copyright 2015 DEÜ. BİD

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