COURSE UNIT TITLE

: TRANSLATIONAL RESEARCH METHODS I

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
TRO 6007 TRANSLATIONAL RESEARCH METHODS I ELECTIVE 1 2 0 15

Offered By

Translational Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR YASEMIN BAŞBINAR

Offered to

Translational Oncology

Course Objective

Translational perspective (from the bed to the lab from the lab to the bed) in cancer, Cancer Research Laboratory and R & D Laboratories Infrastructure, the sampling in cancer research, laboratory space of clinical trials, the diagnostic laboratory techniques, the laboratory techniques that provide for treatment response, tumor models (in vivo in vitro ex vivo, in silico, in toto) Biobanking in cancer research, imaging techniques in cancer research, cell culture (basic techniques, transformation, cellular modulations, culture (cell therapy, stem cells, etc., cytotoxicity, apoptosis, metastasis, invasion studies), treatment technologies will be discussed.

Learning Outcomes of the Course Unit

1   1. Capable of implementing advance molecular techniques for cancer research.
2   2. Be able to know and apply methods for distinguishing individual differences
3   3. Be able to critically evaluates the published literature in the field of cancer research methods
4   4. Be able to recognize and comprehend the treatment technologies
5   5. Be able to recognize and comprehend the molecular diagnostics in cancer
6   6. Be able to establish a laboratory on cancer research.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Cancer Research Laboratory and R & D Laboratory Infrastructure,
2 Stages in Cancer Research (sample preparation, purification, spectral techniques immune techniques, electrophoresis, blotting, hybridization, microscopy)
3 The cell and organelle isolation in cancer research
4 The isolation of macromolecules (DNA, RNA, protein) 1
5 The isolation of macromolecules (DNA, RNA, protein) 2
6 PCR in cancer research 1
7 PCR in cancer research 2
8 Research methods in cancer epigenetics
9 Special staining and imaging techniques in cancer research 1
10 Special staining and imaging techniques in cancer research 2
11 The cell culture (basic techniques, transformation) 1
12 The cell culture (basic techniques, transformation) 2
13 Cellular modulations (cellular therapy, stem cells, etc., cytotoxicity, apoptosis, metastasis, invasion studies) 1
14 Cellular modulations (cellular therapy, stem cells, etc., cytotoxicity, apoptosis, metastasis, invasion studies) 2
15 Debates

Recomended or Required Reading

Molecular Biology of the Cell, 6th Edition. Ed. Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter. Garland Publishers
Essential Cell Biology - 4th Edition Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander D Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter Garland Publishers
The Biology of Cancer, 2nd Edition, Robert A. Weinberg, Garland Publishers
Molecular Biology of the Gene, 7th edition, James Watson, Alexander Gann, Tania Baker, Michael Levine, Stephan Bell, Richard Losick, Stephan Harrison Pearson Cold Spring harbor Laboratory Press.
Principles of Molecular Diagnostics and Personalized Cancer Medicine, Dongfeng Tan, henry Lynch, Wolters Kluwer, Lippincott Williams&Wilkins.
The Handbook of Biomarkers, Kewal Jain, Humana Press
Translational and Experimental Clinical Research, Daniel Schuster, William Powers, Lippincott Williams&Wilkins.

Planned Learning Activities and Teaching Methods

Lectures, the topics with classroom activities (presentations and homework assignments) to consolidate and discussion

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 PRF PERFORMANCE
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE MTE * 0.20 +PRF * 0.20 + FIN* 0.60
5 RST RESIT
6 FCGR FINAL COURSE GRADE MTE * 0.20 +PRF * 0.20 +RST* 0.60


*** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

1. The learner will clearly define outlined LO1, LO2, LO4, LO5 and which will evaluate with exam.
2. The learner will recognize LO3, LO6 will evaluate with homework, prepared presentations by themselves and exam.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

yasemin.baskın@deu.edu.tr ; 0 232 412 58 01

Office Hours

Friday 11:00-12:00

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 2 30
Tutorials 15 1 15
Preparations before/after weekly lectures 15 6 90
Preparation for midterm exam 1 28 28
Preparation for final exam 1 40 40
Preparing assignments 15 6 90
Preparing presentations 10 8 80
Final 1 1 1
Midterm 1 1 1
TOTAL WORKLOAD (hours) 375

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12
LO.1555555
LO.255555555
LO.3555555
LO.45555555
LO.555555555
LO.655555555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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