COURSE UNIT TITLE

: GENOME EDITING TECHNOLOGIES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
MBG 6111 GENOME EDITING TECHNOLOGIES ELECTIVE 3 0 0 12

Offered By

Molecular Biology and Genetics

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR ŞERIFE ESRA ERDAL BAĞRIYANIK

Offered to

Molecular Biology and Genetics
Biomedicine and Health Technologies

Course Objective

This course s aim is to discuss the recent developments and applications of plant genetics and genomics, and the potentials to improve agricultural yield and quality and identify plant molecular mechanism.

Learning Outcomes of the Course Unit

1   To understand the basis of genome editing technology.
2   To explain the recent applications on genome editing for crop improvement
3   To know the metabolome profiling in plants.
4   To understand the basis of metabolic engineering approaches.
5   To understand the basics of CRISPR/Cas9 based metabolic engineering in plants.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Basic of plant genome
2 Genome editing approaches
3 Site specific nucleases
4 CRISPR/Cas9 based editing
5 Genome editing in plants
6 Off targets
7 Midterm exam
8 Basic of plant metabolome
9 Metabolome profiling
10 Secondary metabolites
11 Metabolomics tools and analyzes
12 Metabolic engineering in plants
13 Genome engineering for metabolites
14 CRISPed crops
15 Metabolites for food
16 Final exam

Recomended or Required Reading

Textbook(s): Targeted Genome Editing Using Site-Specific Nucleases, Springer ISBN 978-4-431-55227-7
Supplementary Book(s): Plant Metabolomics, Springer ISBN: 978-1-61779-593-0 (Print) 978-1-61779-594-7 (Online)
References: Applications of Plant Metabolic Engineering Springer, ISBN 978-1-4020-6030-4
Materials: Genebanks, miRBase, NCBI genome, SRA and transcriptome databases, Metlin

Planned Learning Activities and Teaching Methods

1- Taught in lecture.
2- Questions and answers.
3- Discussion.
4- Homework.

Assessment Methods

Successful / Unsuccessful


*** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None.

Assessment Criteria

To be announced.

Language of Instruction

English

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

To be announced.

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 14 3 42
Preparations before/after weekly lectures 14 6 84
Preparation for midterm exam 1 30 30
Preparation for final exam 1 37 37
Preparing assignments 12 5 60
Preparing presentations 2 20 40
Final 1 3 3
Midterm 1 4 4
TOTAL WORKLOAD (hours) 300

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8
LO.13
LO.22
LO.32
LO.42
LO.52