COURSE UNIT TITLE

: METABOLIC DISMUTATION

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
KIM 6015 METABOLIC DISMUTATION ELECTIVE 3 0 0 7

Offered By

Graduate School of Natural and Applied Sciences

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR LEMAN TARHAN

Offered to

Chemistry
Chemistry

Course Objective

How radicals causing toxic effect form and the dismutation reactions occuring against this toxic effect will be enlightened by discussing permanent damages, degenerative diseases and ageing periods which occur in organism in the case of imbalance between radicals and defence system although there is an antioxidant defence system on the purpose of scavenging these free radicals forming in metabolism.

Learning Outcomes of the Course Unit

1   Have a full information about free radicals,
2   Comprehend enzymatic and non-enzymatic antioxidant systems,
3   Understand scavenging mechanisms of free oxygen radicals by antioxidants,
4   Correlate between oxidative stress and diseases,
5   Examine roles of antioxidants in ageing, nutrition, diseases and therapy.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction to Oxygen Toxicity ve Reactive Oxygen Species
2 Free Radical Species
3 Free Radical Sources in Aerobes
4 Antioxidant and Defence Enzymes: Superoxide Dismutases (SOD)
5 Antioxidant and Defence Enzymes: Catalases
6 Antioxidant and Defence Enzymes: Glutathione Peroxidase Family
7 Glutathione Metabolism: Glutathione Peroxidase, Glutathione S-Transferase, Glutathione Reductase
8 Midterm Exam
9 Other Antioxidant Enzymes: Cytochrome c Oxidase, NADPH Peroxidase/Oxidase
10 Non-Enzymatic Antioxidant System: Ascorbic Acid, Vitamine E, - Tocopherol
11 Antioxidant Defence with Low Molecular Weight Agents: Bilirubin, Melatonin, Coenzyme Q, Dipeptides Including Histidine
12 Roles of Metal Ions in Antioxidant Defence System
13 Oxidative Stress and Diseases; The Roles of Antioxidants in Ageing, Nutrition, Diseases and Therapy
14 Homework and Presentations

Recomended or Required Reading

Textbook(s): Barry Halliwell and John M. C. Gutteridge, Free Radicals in Biology and Medicine, Oxford Science Publications, 2001.
Supplementary Book(s): Ruma Banerjee, Donald Becker, Martin Dickman, Vadim Gladyshev, Stephen Ragsdale, Redox Biochemistry, Wiley, 2007.

Planned Learning Activities and Teaching Methods

1. Presentation
3. Question-answer technique
3. Homework

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 ASG ASSIGNMENT
3 PRS PRESENTATION
4 FIN FINAL EXAM
5 FCG FINAL COURSE GRADE MTE* 0.30 + ASG * 0.20 + PRS * 0.10 + FIN * 0.40
6 RST RESIT
7 FCGR FINAL COURSE GRADE (RESIT) MTE* 0.30 + ASG * 0.20 + PRS * 0.10 + RST * 0.40

Further Notes About Assessment Methods

If the instructor needs to add some explanation or further note, this column can be selected from the DEBIS menu.

Assessment Criteria

Meaningful learning of the basic concepts given in presentations, association of concepts with each other, establishing the cause-result relationships and making comments by using the information available for problems and evaluating idea generation are carried out with mid-term and final exams, homework and presentations.

Language of Instruction

Turkish

Course Policies and Rules

Optional, if the instructor needs to add some explanation or further note, this column can be selected from the DEBIS menu.

Contact Details for the Lecturer(s)

leman.tarhan@deu.edu.tr

Office Hours

Wednesday 13.30 - 15.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 13 3 39
Preparation before/after weekly lectures 13 3 39
Preparing Homework and Presentations 1 26 26
Preparation for Final Exam 1 30 30
Preparation for Mid-term Exam 1 25 25
Final 1 2 2
Mid-term 1 2 2
TOTAL WORKLOAD (hours) 163

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11
LO.15555555
LO.255555555
LO.35555555
LO.45555555
LO.555555555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

Copyright 2012 DEÜ. BİD

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