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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS BYM 0637 CANCER MOLECULAR BIOLOGY ELECTIVE 2 0 0 6

Offered By

Graduate School of Natural and Applied Sciences

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR KEMAL SAMI KOKMAZ

Offered to

Industrial Ph.D. Program In Advanced Biomedical Technologies

Course Objective

To have a experimantal and research knowledge of molecular mechanism of cancer

Learning Outcomes of the Course Unit

1   Understanding the cell cycle and the molecular mechanisms of check points 2   Understanding the oncogenes and their activation 3   Understanding the cell cycle, and tumor suppressors and their repression 4   RTKinases and the mechanisms of activation 5   DNA damage and signaling, DD Response 6   Cancer therapy targets, methods of targeting and intervention

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 Introduction to Cancer 2 DNA structure and stability, mutations, Carcinogens, repair mech. 3 Regulation of Gene expression, general transcription factors and the regulation of Chromatin remodeling 4 Regulation of Gene expression, tissue specific transcription factors and the regulation of Chromatin remodeling 5 Growth Factor signaling and the Oncogenes, Kinases, RAS signaling 6 Growth Factor signaling and the tumor supressors, RB, p53 pathways 7 Midterm Exam 8 Stem cells and the Wnt, Hh pathways 9 Metastasis, extravasation, angiogenesis 10 Matrix metalloproteinases 11 Inflammation and the cancer, ROS mediated DNA damage 12 Steroid reseptors and their role in cancer progression 13 Prostat cancer and the androgen receptor 14 Intervention therapies and the new modalities, approaches

Recomended or Required Reading

Molecular Biology of Cancer, Lauren Pecorino, Oxford press, 2005, current articles (pubmed)

Planned Learning Activities and Teaching Methods

homework

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 MTE MIDTERM EXAM 2 FIN FINAL EXAM 3 FCG FINAL COURSE GRADE MTE * 0.40 + FIN * 0.60 4 RST RESIT 5 FCGR FINAL COURSE GRADE (RESIT) MTE * 0.40 + RST * 0.60

Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

Assoc.Prof.Dr. Kemal Sami Korkmaz

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 12 3 36 Preparations before/after weekly lectures 12 3 36 Preparation for midterm exam 1 30 30 Preparation for final exam 1 40 40 Preparing assignments 1 10 10 Midterm 1 2 2 Final 1 2 2 TOTAL WORKLOAD (hours) 156

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 PO.8 PO.9 PO.10 LO.1 5 LO.2 4 5 LO.3 2 3 LO.4 LO.5 5 4 LO.6