COURSE UNIT TITLE

: STEM CELL ENGINEERING

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
BMT 0611 STEM CELL ENGINEERING ELECTIVE 3 0 0 6

Offered By

Graduate School of Natural and Applied Sciences

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASISTANT PROFESSOR AYLIN ŞENDEMIR ÜRKMEZ

Offered to

Industrial Ph.D. Program In Advanced Biomedical Technologies

Course Objective

To overview historic milestones of stem cell research;to examine the role of stem cells in development, tissue homeostasis, and wound healing, as well as how they have been used for tissue engineering and cell-based regeneration therapies; to define biological aspects of stem cells; to learn the practical use of these cells for tissue regeneration applications; to discuss the ethical, legal, and regulatory issues that accompany current and emerging stem cell engineering applications.

Learning Outcomes of the Course Unit

1   To learn different types of stem cells,
2   Understand the current challenges in stem cell engineering applications,
3   To learn differentiation process of stem cell into different cell types.
4   To learn how to make a literature review in order to find a technical paper on any subject of the course, to read, summarize and present the study orally.
5   To be able to discuss ethical issues in stem cells usage in regenerative medicine.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction to stem cell engineering, historic milestones of stem cell research, basic concepts of stem cells, stem-cell properties, telomeres and self-renewal;
2 Classification of stem cells, embryonic stem cells, mesenchymal stem cells,
3 Classification of stem cells, endothelial progenitor cells, neuronal stem cells, liver stem cells, induced pluripotent stem cells;
4 Cellular-Fate processes, stem cell differentiation, migration and death;
5 Coordination of cellular-fate processes, soluble signals, stem cell-extracellular matrix interactions, response to mechanical stimuli;
6 Important aspects for culturing different types of stem cell in vitro;
7 Culturing stem cells in biomaterial scaffolds, biomaterial properties, types of biomaterials
8 Tailoring biomaterials, tailoring surface chemistry and topography, synthetic peptides, functions of synthetic peptides;
9 Examples of stem cell usage in regenerative medicine, osteogenic and chondrogenic differentiation of mesenchymal stem cells;
10 Examples of stem cell usage in regenerative medicine, vasculogenesis, vasculogenic differentiation of endothelial progenitor cells;
11 Stem cells and cancer, cancer stem cells, current techniques to target cancer stem cells in cancer tissue;
12 Ethical issues in stem cell engineering applications;
13 Student Presentations;
14 Student Presentations;

Recomended or Required Reading

1. Bernhard Palsson, Sangeeta N. Bhatia, Tissue Engineering , Pearson (2004).
2. Artmann, Gerhard M.; Minger, Stephen; Hescheler, Jürgen, Stem Cell Engineering (Principles and Applications) ,Springer (2011).
3. Scientific articles provided during the semester

Planned Learning Activities and Teaching Methods

Project and exams

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 ASG ASSIGNMENT
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE MTE * 0.20 + ASG * 0.20 + FIN * 0.60
5 RST RESIT
6 FCGR FINAL COURSE GRADE (RESIT) MTE * 0.20 + ASG * 0.20 + RST * 0.60

Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

English

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

To be announced.

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 14 3 42
Preparations before/after weekly lectures 14 2 28
Preparation for midterm exam 1 20 20
Preparation for final exam 1 20 20
Design Project 1 25 25
Preparing presentations 1 1 1
Reading 14 1 14
Final 1 2 2
Midterm 1 2 2
TOTAL WORKLOAD (hours) 154

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10
LO.125313
LO.225
LO.333
LO.452
LO.51

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

Copyright 2012 DEÜ. BİD

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