COURSE UNIT TITLE

: MOLECULAR MECHANISMS OF DISEASE

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
BIO 6056 MOLECULAR MECHANISMS OF DISEASE ELECTIVE 2 2 0 15

Offered By

The Institute Of Health Sciences

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR AYŞE SEMRA KOÇTÜRK

Offered to

The Institute Of Health Sciences
Histology and Embryology
Medical Biology and Genetics
Anatomy
Basic Oncology
Toxicology
Biochemistry
Biophysics
Physiology
Medical Physics
Microbiology
Pharmacology
Molecular Medicine

Course Objective

The aim of this course is intensify the knowledge of postgraduate students that they have taken for the duration of training period on biochemistry, microbiology, genetics, and medical biology with molecular metabolism of diseases and metabolic pathways that forms a basis of diseases.
In the application section of the course will provide to learners how to implement the current analytical techniques in hospital laboratory to monitor and diagnosis of diseases. All application demonstrations will put into practice under the guidance of a faculty member.
Knowledge of analyses that unconventional in Dokuz Eylul Hospital Laboratory will support by case report and clinical correlations, which approve by instructor.

Learning Outcomes of the Course Unit

1   Be able to comprehend and understand of the basic metabolism and biochemistry knowledge (Knowledge).
2   Be able to have a basic molecular mechanism (Knowledge)
3   Be able to reach information and data-base related with the application area.(skill)
4   Be able to interpret various problems on various diseases (skill)
5   Learner has skills that present their knowledge on molecular mechanisms of diseases to academic and non-academic communities effectually (know-how)

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Endocrine system diseases and diagnosis in y-the lab.Tyroid, Hypothalamus- hypophis Neoplastic diseases and mechanisms,Neoplastic diseae markers, Inflectional diseases and molecular mechanisms,Diagnosis techniques, Molecular mechanisms of blood diseases,Hemoglobinopathies, anemia, Thalasemia, G6PDH deficiency
2 Otoimmun diseases.Markers of otoimmun deficiencies. Molecular Mechanism of cardiac diseases,Atherosclerosis,Myocardial infracts, plasma enzymes and marker proteins.Markers of cardiac obstruction, Kidney structure and function,Water, Na, K, Ca, Pi, Mg homeostasis and diseases.Renal function tests, GIS s diseases molecular mechanism,Liver function tests, plasma proteins,Hepatitis, Kolelitiasis,DM,
3 Molecular mechanism of Aging nd degenerative diseases. Laboratory analysis Molecular mechanism of connective tissue diseases.Molecular markers Molecular principles of metabolic diseases.Screening and diagnosis tecniques in lab. Molecular principles of Genetic diseases.Screening and diagnosis tecniques in lab. Diseases of cell mebrane and cellular skeletal system.Mitochondrial-lysosomal diseases.

Recomended or Required Reading

1. Biology of Disease. Eds: Ahmed N., Dawson M., Smith C., Wood E. 2007 by Taylor and &Francis Group, New York.
2. Textbook of Clinical Chemistry and Molecular Diagnostics. Eds: Burtis CA, Ashwood ER, Bruns DE, 4th edition, 2006, Elsevier Saunders, St Louis.
3. Textbook of Biochemistry with Clinical Correlations. Sixth edition. 2005, Ed. Thomas M. Devlin. John-Wiley& Sons Inc. Publication, USA
4. Human Molecular genetics 3. Tom Strachan and Andrew P. Read. Garland Science, UK 2004
5. Thompson and Thompson genetics in Medicine. Nussbaum RL, McInnes RR, Huntington FW. (Çeviri kitap). Güneş Kitabevi. Ankara,2005
6. Alonso AC, Li B, Grundke-Iqbal I, Iqbal K. Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies.Curr Alzheimer Res. 2008 Aug;5(4):375-84. Review.

Planned Learning Activities and Teaching Methods

Comprehension of theoretical knowledge on molecular mechanisms of diseases will provide by lectures and learning of analytical technics will provide by application sections in hospital laboratory.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 ASG ASSIGNMENT
2 PAR PARTICIPATION
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE ASG * 0.30 +PAR * 0.30 +FIN* 0.40
5 RST RESIT
6 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.30 +PAR * 0.30 +RST* 0.40

Further Notes About Assessment Methods

None

Assessment Criteria

1. Learner theoretical knowledge on molecular mechanism of diseases will evaluated with assignments, laboratory works and final exam
2. Learner skills on to reach information and data-base related with the application area, planning of experiment will evaluate via assignments
3. Learner knowledge on basic laboratory technics that will use monitoring and diagnosis of disease will evaluate via all application sessions and an assignment

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

semra.kocturk@deu.edu.tr, 4124407

Office Hours

on Tuesday at: 13.30-16.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 30 1 30
Tutorials 30 1 30
Preparing assignments 3 50 150
Preparing presentations 3 40 120
Preparation for final exam 1 42 42
Final 1 3 3
TOTAL WORKLOAD (hours) 375

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10
LO.1
LO.2
LO.3
LO.4
LO.5