COURSE UNIT TITLE

: CANCER BIOLOGY CAND GENETICS

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
TBG 6083 CANCER BIOLOGY CAND GENETICS ELECTIVE 3 0 0 15

Offered By

Medical Biology and Genetics

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR SAFIYE NEŞE ATABEY

Offered to

Medical Biology and Genetics

Course Objective

Understanding of the common cellular, molecular and genetic mechanisms that are deregulated in cancerous cells, and how does their deregulation contribute to the development of cancer . Formulating how genomic technologies provide insight into cancer prevention, diagnosis, and treatment .To learn up-to-date knowledge of familial cancers and their sporadic forms.

Learning Outcomes of the Course Unit

1   Discusses microevolution of cancer cells
2   Defines common cancer-critical genes and molecular mechanisms that are deregulated in cancerous cells, and how does their deregulation contribute to the development of cancer.
3   Explains the role of genetic and epigenetic mechanisms in the development of cancer
4   Describes ways of environmental factors (viral, chemical and physical carcinogens) influence cancer susceptibility and knows how may we use this information to prevent cancer
5   Formulates how does cancer manifest itself in the human body, Explains the roles of tumor-microenvironment interactions during cancer initiation and progression
6   Discusses the roles of genomic technologies provide insight into cancer prevention, diagnosis, and treatment and their limitations.
7   Knows sporadic and familial cancer concepts.
8   Knows mutation types of involved genes in both sporadic and familial cancers
9   Knows inheritance patterns, penetrance, and expressivity of genes involved in familial cancers.
10   Knows pathways affected by genes involved in familial cancers.
11   Establishes and evaluates a pedigree and to know risk assessment principles in cancer predisposition.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Terminology, hypothesis for the cancer mechanisms
2 Common genetics and epigenetics mechanisms that are deregulated in cancerous cells, and their roles to the development of cancer (CASE 1).
3 The effects of environmental factors on cancer susceptibility and cancer prevention (CASE 2)
4 The roles of microorganisms in the development of cancer (CASE 3)
5 The roles of signaling during carcinogenesis (CASE 4)
6 The roles of signaling in tumor-microenvironment during cancer initiation and progression
7 The roles of genomic technologies provide insight into cancer prevention, diagnosis, and treatment and their limitations
8 Cancer stem cells and their role in carcinogenesis
9 Hormonal Malignity Syndromes (Early onset breast cancer; Cowden Syndrome; Li-Fraumeni Syndrome; Prostate cancer)
10 Endocrine Cancers (MEN1, MEN2)
11 Hamartoma Syndromes (Neurofibromatosis 1, Von Hippel Lindau)
12 DNA Repair Defects (Fanconi anemia, Ataxia telangiectasia, Bloom syndrome; Xeroderma pigmantosum)
13 Embryonic neoplasms (Retinoblastoma; Wilm s Tumor)
14 Gastrointestinal Malignity (Familial Polyposis; HNPCC)
15 Skin Cancer (Melanoma, Gorlin syndrome)
16 Final Exam

Recomended or Required Reading

Ana kaynak: Up to date review/ research articles from journals with high impact factors Alberts, etal. Molecular Biology of the Cell, Fifth ed., Garland Sciences.
Yardımcı kaynaklar: 1. Kumar etal., Robbins and Cotran Pathologic Basis of Disease, Seventh ed., Elsevier Saunders. 2. G.M.Cooper, The Cell A Molecular Approach, Third ed.,ASM Press, Sinauer Associates Inc.,

Planned Learning Activities and Teaching Methods

In this course , main learning method is Problem Based Learning . Learning objectives of the course will be given by case studies and related lectures . In addition:
Oral Presentations: Basic information, especially the subjects that are hard to understand or unreachable will be given by tutor.
Tutorials: Some up to date articles related to the basic subjects will be chosen and students will be asked to read and discuss.
Home Work: Several questions aiming to increase the synthesis and analysis abilities of students will be given and asked for a written report. In addition students prepares concept maps related to case studies.
Interactive student presentations: Each student is expected to make a presentation and prepare a poster on a particular type of familial cancer.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 ASG ASSIGNMENT
3 PAR PARTICIPATION
4 FIN FINAL EXAM
5 FCGR FINAL COURSE GRADE MTE * 0.30 + ASG * 0.20 +PAR* 0.10 + FIN*0.40
6 RST RESIT
7 FCGR FINAL COURSE GRADE (RESIT) MTE * 0.30 + ASG * 0.20 +PAR* 0.10 + RST*0.40

Further Notes About Assessment Methods

None

Assessment Criteria

Written Exams: At least 75% of questions should be answered correctly.
LO 1-6: Concept maps: The group will be expected to prepare a concept map for each cases and critique pointing out the concepts of the case study. Students will be expected to contribute to the discussion and critique of the case being presented in the class. (Reading the papers before the presentation is absolutely mandatory).
LO 7-10: A selected subject on a particular type of familial cancer will be presented in the class.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

Tlf: 232. 4124600 or 232.4124601
nese.atabey@deu.edu.tr

Office Hours

From Monday to Friday at 12:00-13:00

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 3 45
small group work 15 3 45
Preparations before/after weekly lectures 15 3 45
Preparation for final exam 1 15 15
Preparing Individual Assignments 10 10 100
Preparing Group Assignments (concept maps) 5 10 50
Preparing Presentations 5 10 50
Preparation for quiz etc. 1 15 15
Final 1 3 3
Quiz etc. 1 3 3
TOTAL WORKLOAD (hours) 371

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9
LO.113
LO.2123
LO.3123
LO.4123
LO.513
LO.61
LO.72
LO.812
LO.92
LO.103
LO.11

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

Copyright 2012 DEÜ. BİD

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