COURSE UNIT TITLE

: ENZYMOLOGY

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
BIO 6048 ENZYMOLOGY ELECTIVE 2 0 0 10

Offered By

Biochemistry

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR GÜL AKDOĞAN

Offered to

Biochemistry
Molecular Medicine

Course Objective

Within the frame of this course, the following topics and concepts are inteded to be discussed at an advanced level:
Historical aspects of enzymology, nomenclature and classification of enzymes, concept of substrate specificity and mecanisms, coenzymes, types, accociated reactions and role in metabolism, control of enzymatic reactions, , enzimatik aktivitenin kontrolü, velocity of enzymatic reactions, chemical kinetics, enzymatic kinetics, inhibition and types, effect of pH, bi-substrate reactions, derivation of Michaelis-menten equation; mecanisms of enzyme catalysis, enzymatic reaction mecanim using the lysosyme example; serine proteases; drug desing, introduction to pharmacology, introduction to clinical enzymology

Learning Outcomes of the Course Unit

1   Learn enyzme definition, classification, general properties of enzymes, enzyme catalysis and catalysis mechanisms at an advanced level
2   Be able to transfer knowledge about basic enzymology to different conditions
3   Understand the different catalysis types and discuss them using different examples
4   Gain skills for transfering basic enzymology information on drug design
5   Starting with enzyme inhibition types, be able to analyse events taking place in the organism and compare the basics of different applications of enzyme therapy
6   Understand the use of different enzymes in clinical enzymology
7   Using the information learned as well as searching new information, prepare and make an oral presentation on a topic in enzymology

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 LECTURE: Introduction to Enzymology- basic concepts Group Work: Enzyme nomenclature and classification of enzymes This activity will take place on the first day of the first week.
2 LECTURE: Substrate specificity, coenzymes, control of enzymatic activity, effect of pH Group Work: Coenzymes and associated reactions This activity will take place on the second day of the first week.
3 LECTURE: Chemical kinetics, Enzyme kinetics Group Work: Enzyme kinetics This activity will take place on the third day of the first week.
4 LECTURE: Enzyme inhibition and types Group Work: Problem solving- enzyme kinetics This activity will take place on the fourth day of the first week.
5 LECTURE: Bisubstarte reactions Group Work: Problem solving- Bi-substrate reactions This activity will take place on the fifth day of the first week.
6 Group Work: Derivation of Michaelis Menten Kinetics This activity will take place on the first day of the second week.
7 LECTURE: Enzyme Catalysis mechanisms Group Work: Discussion on mechanisms This activity will take place on the second day of the second week.
8 LECTURE: Lysosyme- Serine proteases, Drug design This activity will take place on the third day of the second week.
9 LECTURE: Use of enzymes in Clinical Laboratory-General principles This activity will take place on the fourth day of the second week.
10 STUDENT PRESENTATIONS General Discussion (Whole Group) This activity will take place on the fifth day of the second week.

Recomended or Required Reading

Textbook(s)/References/Materials:
1. Harper s Illustrated Biochemistry 28th Edition, 2009 , Murray, Bender, Rotham, Kennelly
Rodwell and Weil.McGraw Hill International Edition.pp51-83.
Yardımcı kaynaklar:
2. Textbook of Biochemistry with Clinical Correlations. Seventh Edition 2011, Thomas M. Devlin. John-Wiley& Sons Inc. Publication, USA , pp. 377-418.
3. Textbook of Clinical Chemistry and Molecular Diagnostics. Eds: Burtis CA, Ashwood ER, Bruns DE, 4th edition, 2006, Elsevier Saunders, St Louis.
4. Newsholme, EA and Leech, TR. Functional Biochemistry in Health and Disease 2010, WILEY-BLACKWELL, Oxford, pp 35-68.
5. Bisswanger, H. Practical Enzymology 2011, WILEY-BLACKWELL.

Planned Learning Activities and Teaching Methods

Lectures, small group sessions, problem solving, making a presentation

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 ASG ASSIGNMENT
3 PAR PARTICIPATION
4 FIN FINAL EXAM
5 FCGR FINAL COURSE GRADE MTE * 0.30 + ASG * 0.20 +PAR* 0.10 + FIN*0.40
6 RST RESIT
7 FCGR FINAL COURSE GRADE (RESIT) MTE * 0.30 + ASG * 0.20 +PAR* 0.10 + RST*0.40

Further Notes About Assessment Methods

None

Assessment Criteria

Optional, if the instructor needs to add some explanation or further note, this column can be selected from the DEBIS menu.

Language of Instruction

Turkish

Course Policies and Rules

Optional, if the instructor needs to add some explanation or further note, this column can be selected from the DEBIS menu.

Contact Details for the Lecturer(s)

Gül Güner Akdoğan
Phone: 2 44 03

Office Hours

Mondays 12.30-13:0, Department of Medical Biochemistry

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 10 2 20
Tutorials 10 1 10
Preparations before/after weekly lectures 10 8 80
Preparation for midterm exam 1 30 30
Preparation for final exam 1 70 70
Preparing presentations 1 35 35
Final 1 3 3
Midterm 1 2 2
TOTAL WORKLOAD (hours) 250

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12PO.13
LO.1544
LO.2555444
LO.3555445
LO.45554455
LO.5555555
LO.655544444454
LO.75555555555555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

Copyright 2012 DEÜ. BİD

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