COURSE UNIT TITLE

: FUNDAMENTAL PRINCIPLES OF GLYCOBIOLOGY

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
KIM 5049 FUNDAMENTAL PRINCIPLES OF GLYCOBIOLOGY ELECTIVE 3 0 0 7

Offered By

Graduate School of Natural and Applied Sciences

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR HÜLYA AYAR KAYALI

Offered to

Chemistry
Chemistry

Course Objective

The chemistry and metabolism of carbohydrates were prominent matters of interest in the first part of the 20th century. The biological roles of carbohydrates are particularly important in the assembly of complex multicellular organs and organisms, which requires interactions between cells and the surrounding matrix. The course aims the structure, metabolism and biological roles of carbohydrates and their derivates as well as the diseases about glycobiology.

Learning Outcomes of the Course Unit

1   Realize carbohydrates and their classification and metabolism,
2   Comprehend the structural basis of glycans and protein-glycan interactions,
3   Understand cellular organization of glycosylation and its precursors,
4   Realize the mechanism of glycan-processing enzymes and glycosyltransferases,
5   Comprehend the role of glycans in genetic disorders and disease.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Historical Background and Overview
2 Carbohydrate Structure/Nomenclature and Evolution of Glycan Diversity
3 Carbohydrate Metabolism
4 Protein-Glycan Interactions
5 Exploring the Biological Roles of Glycans
6 Glycosphingolipids and Their Anchors
7 Proteoglycans and Glycosaminoglycans
8 Midterm Exam
9 Nuclear and Cytoplasmic Glycosylation
10 Sialic Acids, Structures Common to Different Types of Glycans
11 Glycosyltransferases
12 Lectins, Selectins and Galectins
13 Carbohydrate- and Glycosaminoglycan- binding Proteins
14 Glycans in Genetic Disorders and Disease

Recomended or Required Reading

Textbook(s):
Supplementary Book(s): Essentials of Glycobiology, Edited by Ajit Varki, Richard D Cummings, Jeffrey D Esko, Hudson H Freeze, Pamela Stanley, Carolyn R Bertozzi, Gerald W Hart, and Marilynn E Etzler. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009. ISBN-13: 9780879697709
References:
Materials:

Planned Learning Activities and Teaching Methods

1. Presentation
2. Interactive narrative
3. Question-answer technique
4. Home work

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 ASG ASSIGNMENT
3 PAR PARTICIPATION
4 FIN FINAL EXAM
5 FCG FINAL COURSE GRADE
6 RST RESIT
7 FCGR FINAL COURSE GRADE (RESIT)

Further Notes About Assessment Methods

None

Assessment Criteria

Meaningful learning of the basic concepts given in presentations, association of concepts with each other, establishing the cause-result relationships and making comments by using the information available for problems and evaluating idea generation are carried out with mid-term and final exams, active participation to the lecture, homework.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

Dokuz Eylül University, Science Faculty, Chemistry Department, Biochemistry Division, 35160, Buca, Izmir, Turkey
e-mail:hulya.kayali@deu.edu.tr
Tel: +90 232 3018690

Office Hours

Wednesday 13.30-15.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 13 3 39
Preparation before/after weekly lectures 13 3 39
Preparation for Mid-term Exam 1 10 10
Preparation for Final Exam 1 20 20
Preparing Presentations 2 15 30
Preparing Group Assignments 2 15 30
Final Exam 1 2 2
Midterm Exam 1 2 2
TOTAL WORKLOAD (hours) 172

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11
LO.15444
LO.25444
LO.354444
LO.454444
LO.5544444